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    dsb debris buster [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dsbprovided by FlyBase
    Official Full Name
    debris busterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035290
    Locus tag
    Dmel_CG1887
    See related
    AllianceGenome:FB:FBgn0035290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1887; Dmel\CG1887; Dsb; ph
    Summary
    Predicted to enable scavenger receptor activity. Involved in phagosome maturation. Located in late endosome membrane; lysosomal membrane; and phagocytic vesicle. Is expressed in several structures, including embryonic/larval anal pad; embryonic/larval anterior spiracle; embryonic/larval fat body; embryonic/larval garland cell; and embryonic/larval posterior spiracle. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; progressive myoclonus epilepsy 4; and pulmonary tuberculosis. Orthologous to several human genes including SCARB2 (scavenger receptor class B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dsb in Genome Data Viewer
    Location:
    62B9-62B10; 3-1.0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1893408..1910197, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1893408..1910197, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Adenine phosphoribosyltransferase Neighboring gene Tetraspan membrane protein in hair cell stereocilia Neighboring gene transfer RNA:Cysteine-GCA 2-1 Neighboring gene long non-coding RNA:CR45826 Neighboring gene Dbx

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trynity models a tube valve in the Drosophila larval airway system. Wang Y, et al. Dev Biol, 2018 May 15. PMID 29518377
    2. Expression of the Scavenger Receptor Class B type I (SR-BI) family in Drosophila melanogaster. Herboso L, et al. Int J Dev Biol, 2011. PMID 21948708
    3. Debris buster is a Drosophila scavenger receptor essential for airway physiology. Wingen A, et al. Dev Biol, 2017 Oct 1. PMID 28821389
    4. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. Yu M, et al. PLoS Genet, 2023 May. PMID 37200393, Free PMC Article
    5. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Han C, et al. Neuron, 2014 Feb 5. PMID 24412417, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dsb sorts components of the apical extracellular matrix which are essential for airway physiology.
      Title: Debris buster is a Drosophila scavenger receptor essential for airway physiology.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    debris buster
    Names
    CG1887-PD
    CG1887-PF
    CG1887-PG
    dsb-PD
    dsb-PF
    dsb-PG
    plush

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1893408..1910197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104007.4 → NP_001097477.1  debris buster, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097477.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNI3
      Conserved Domains (1) summary
      pfam01130
      Location:103 → 532
      CD36; CD36 family

    2. NM_139418.3 → NP_647675.3  debris buster, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647675.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY22
      Conserved Domains (1) summary
      pfam01130
      Location:5 → 434
      CD36; CD36 family

    3. NM_001274370.1 → NP_001261299.1  debris buster, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261299.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAR1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNI3 A8JNI3
    F0JAR1 F0JAR1
    R9PY22 R9PY22

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