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    sturkopf sturkopf [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38150, updated on 17-Dec-2024

    Summary

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    Official Symbol
    sturkopfprovided by FlyBase
    Official Full Name
    sturkopfprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035206
    Locus tag
    Dmel_CG9186
    See related
    AllianceGenome:FB:FBgn0035206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9186; Dmel\CG9186; LDAH; Sturkopf
    Summary
    Enables serine hydrolase activity. Involved in several processes, including lipid droplet organization; negative regulation of juvenile hormone metabolic process; and sequestering of triglyceride. Located in endoplasmic reticulum and lipid droplet. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; embryonic/larval salivary gland; and salivary gland body primordium. Orthologous to human LDAH (lipid droplet associated hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sturkopf in Genome Data Viewer
    Location:
    61F6-61F6; 3-0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1311719..1313377, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1311719..1313377, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Acetyl-CoA acetyltransferase 2 Neighboring gene 5' nucleotidase A Neighboring gene Ctr9 Neighboring gene HECT and RLD domain containing E3 ubiquitin ligase 4 Neighboring gene Myosin 61F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics. Oliva MK, et al. Front Neurosci, 2020. PMID 32903680, Free PMC Article
    2. Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics. Pérez-Moreno JJ, et al. J Cell Biol, 2023 Jun 5. PMID 36952540, Free PMC Article
    3. The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective. Bresgen N, et al. Biomolecules, 2023 May 30. PMID 37371492, Free PMC Article
    4. Drosophila embryos spatially sort their nutrient stores to facilitate their utilization. Kilwein MD, et al. Development, 2023 Oct 15. PMID 36805634, Free PMC Article
    5. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Kory N, et al. Dev Cell, 2015 Aug 10. PMID 26212136, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sturkopf mutation affects lipid storage, juvenile hormone and insulin signaling. The survival and response to dietary changes is altered in Sturkopf mutants.
      Title: Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf.
    2. In targeted experiments, authors analyzed the two proteins Jabba and CG9186 in greater detail. Jabba mediates the sequestration of histones to lipid droplets.
      Title: A Luciferase-fragment Complementation Assay to Detect Lipid Droplet-associated Protein-Protein Interactions.
    3. this study identified a novel lipid droplets -associated protein family, represented by the Drosophila protein CG9186 and its murine homolog MGI:1916082.
      Title: The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables monoacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    NOT enables triacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of juvenile hormone metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sequestering of triglyceride IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sturkopf
    Names
    CG9186-PA
    CG9186-PB
    sturkopf-PA
    sturkopf-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1311719..1313377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138253.2 → NP_612097.1  sturkopf, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0H3
      Related
      FBpp0072611, FBtr0072727
      Conserved Domains (2) summary
      COG0596
      Location:4 → 304
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam10230
      Location:28 → 286
      DUF2305; uncharacterized conserved protein (DUF2305)

    2. NM_167867.2 → NP_728590.1  sturkopf, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728590.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0H3
      Related
      FBpp0072612
      Conserved Domains (2) summary
      COG0596
      Location:4 → 304
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam10230
      Location:28 → 286
      DUF2305; uncharacterized conserved protein (DUF2305)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0H3.1 Q9W0H3

    Gene LinkOut

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