Mmp2 Matrix metalloproteinase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mmp2provided by FlyBase
Official Full Name: Matrix metalloproteinase 2provided by FlyBase
Primary source: FLYBASE:FBgn0033438
Locus tag: Dmel_CG1794
See related: AllianceGenome:FB:FBgn0033438
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2-MMP; anon-WO0118547.84; CG1794; dm-2MMP; Dm2-MMP; Dmel\CG1794; dmmp2; dMMP2; l(2)02353; mmp2; MMP2; SN2-2
Summary: Enables metalloendopeptidase activity. Involved in several processes, including embryonic heart tube development; imaginal disc morphogenesis; and open tracheal system development. Located in dendrite; external side of plasma membrane; and extracellular space. Is expressed in several structures, including brain; glial cell; imaginal disc; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to several human genes including MMP15 (matrix metallopeptidase 15). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 45F6-46A1; 2-61 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9611139..9683858, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5498644..5571363, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila.
Title: Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila.
there are only two MMP genes in Drosophila, DmMmp1 and DmMmp2, which makes Drosophila an attractive system to analyze the basis of MMP specificity. Previously, Drosophila MMPs have been categorized by their pericellular localization, as Mmp1 appeared to be secreted and Mmp2 appeared to be membrane-anchored, suggesting that protein localization was the critical distinction in this small MMP family
Title: Both Drosophila matrix metalloproteinases have released and membrane-tethered forms but have different substrates.
inhibition of ECM degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration
Title: Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.
Data indicate that matrix metalloproteinases mmp1 and mmp2 mutants have distinct heart phenotypes.
Title: Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development.
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2+ as the second messenger.
Title: A Follicle Rupture Assay Reveals an Essential Role for Follicular Adrenergic Signaling in Drosophila Ovulation.
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.
Title: Matrix metalloproteinase 2 is required for ovulation and corpus luteum formation in Drosophila.
As a Wnt signaling antagonist, MMP2 cleaves the glypican, reducing the ability of Dlp to interact with the Wnt ligand and promote its distribution.
Title: A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation.
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila
Title: ßFTZ-F1 and Matrix metalloproteinase 2 are required for fat-body remodeling in Drosophila.
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Title: Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes
Title: Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase-mediated modification of the basement membranes.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0329 (e-PCR)
- UniSTS:37618

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in adult fat body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast migration to the midline involved in heart rudiment formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic heart tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fasciculation of motor neuron axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc eversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in substrate-dependent cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal pit formation in open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: matrix metalloproteinase 2

Names: CG1794-PB; CG1794-PC; CG1794-PD; Mmp2-PB; Mmp2-PC; Mmp2-PD; matrix metalloprotease 2; matrix metalloproteinase; matrix metalloproteinase-2; matrix metalloprotinase 2; suppressor of NA9 2-2

NP_001260830.1

EC 3.4.24.-

NP_610511.3

EC 3.4.24.-

NP_995788.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9611139..9683858 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206066.3 → NP_995788.1 matrix metalloproteinase 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995788.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4KFG9, A0A0C4DHC9, Q5BIL2, Q8MPP3

Conserved Domains (3) summary

cd00094
Location:513 → 707

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:143 → 301

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:143 → 301

Peptidase_M10; Matrixin
NM_001273901.1 → NP_001260830.1 matrix metalloproteinase 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260830.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MPP3

Conserved Domains (3) summary

cd00094
Location:361 → 555

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:8 → 149

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:8 → 149

Peptidase_M10; Matrixin
NM_136667.3 → NP_610511.3 matrix metalloproteinase 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610511.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MPP3

Conserved Domains (3) summary

cd00094
Location:405 → 599

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:52 → 193

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:44 → 193

Peptidase_M10; Matrixin