Gpb5 Glycoprotein hormone beta 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gpb5provided by FlyBase
Official Full Name: Glycoprotein hormone beta 5provided by FlyBase
Primary source: FLYBASE:FBgn0063368
Locus tag: Dmel_CG40041
See related: AllianceGenome:FB:FBgn0063368
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: beta-glycoprotein-hormone-related; CG40041; Dmbeta; Dmel\CG40041; gpb5; GPB5
Summary: Enables protein heterodimerization activity. Contributes to G protein-coupled receptor binding activity and hormone activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in adult GPA2/GPB5 neuron of the ventral nerve cord and larval GPA2/GPB5 neuron of the ventral nerve cord. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Orthologous to several human genes including GPHB5 (glycoprotein hormone subunit beta 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (23311700..23312464)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2LHet	NW_001848855.1 (167215..167979)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila GPA2/GPB5 heterodimers did not activate human TSH or gonadotropin receptors, chimeric fly GPA2/human GPB5 heterodimers stimulated human TSH receptors.
Title: Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.

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Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Function	Evidence Code	Pubs
contributes_to G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IC Inferred by Curator more info	PubMed

Names: CG40041-PA; CG40041-PC; CG40041-PD; Gpb5-PA; Gpb5-PC; Gpb5-PD; beta-glycoprotein-hormone-related; beta-glycoprotein-hormone-related-polypeptide; glycoprotein hormone beta 5 ortholog

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