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    CG4390 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4390provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038771
    Locus tag
    Dmel_CG4390
    See related
    AllianceGenome:FB:FBgn0038771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4390
    Summary
    Enables serine hydrolase activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be active in cytosol. Is expressed in organism. Orthologous to human ESD (esterase D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4390 in Genome Data Viewer
    Location:
    92C4-92C4; 3-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20056418..20059750, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15882140..15885472, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Regnase 1 Neighboring gene identity crisis Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene I'm not dead yet 2 Neighboring gene midlife crisis Neighboring gene Rhodopsin 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster. Appel M, et al. PLoS One, 2015. PMID 25992709, Free PMC Article
    2. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    3. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    4. SUMO-Enriched Proteome for Drosophila Innate Immune Response. Handu M, et al. G3 (Bethesda), 2015 Aug 18. PMID 26290570, Free PMC Article
    5. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-formylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-formylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in formaldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4390-PA
    CG4390-PB
    NP_650864.1
    NP_732486.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20056418..20059750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169887.2 → NP_732486.2  uncharacterized protein Dmel_CG4390, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732486.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUZ3, Q7KSB5
      Related
      FBpp0083245
      Conserved Domains (2) summary
      COG0627
      Location:45 → 330
      FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
      cl21494
      Location:48 → 326
      Abhydrolase; alpha/beta hydrolases

    2. NM_142607.2 → NP_650864.1  uncharacterized protein Dmel_CG4390, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUZ3, Q9VDP9
      Related
      FBpp0083246
      Conserved Domains (2) summary
      COG0627
      Location:1 → 286
      FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
      cl21494
      Location:4 → 282
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KSB5 Q7KSB5
    Q9VDP9 Q9VDP9

    Gene LinkOut

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