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    Ack Activated Cdc42 kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ackprovided by FlyBase
    Official Full Name
    Activated Cdc42 kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028484
    Locus tag
    Dmel_CG14992
    See related
    AllianceGenome:FB:FBgn0028484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACK; ACK2; BcDNA:GH10777; CG14992; dACK; DAck; DACK; Dmel\CG14992; p145
    Summary
    Enables DNA-binding transcription factor binding activity; non-membrane spanning protein tyrosine kinase activity; and protein domain specific binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; embryonic development via the syncytial blastoderm; and negative regulation of hippo signaling. Acts upstream of with a positive effect on phospholipid metabolic process. Located in cell periphery; clathrin-coated vesicle; and cytoophidium. Part of protein-containing complex. Is expressed in adult head; embryonic leading edge cell; mitotic domain; and organism. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ack in Genome Data Viewer
    Location:
    64A6-64A6; 3-10 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4108186..4114157)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4108186..4114157)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45670 Neighboring gene Fermitin 1 Neighboring gene Chd64 Neighboring gene ensconsin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ack kinase regulates CTP synthase filaments during Drosophila oogenesis. Strochlic TI, et al. EMBO Rep, 2014 Nov. PMID 25223282, Free PMC Article
    2. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. Worby CA, et al. J Biol Chem, 2001 Nov 9. PMID 11546816
    3. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Schmucker D, et al. Cell, 2000 Jun 9. PMID 10892653
    4. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Sem KP, et al. Mol Cell Biol, 2002 Jun. PMID 11997505, Free PMC Article
    5. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Clemens JC, et al. Proc Natl Acad Sci U S A, 2000 Jun 6. PMID 10823906, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flies deficient in DAck catalytic activity have morphologically abnormal CTP synthase filaments, reduced RNA levels, membrane phospholipid defects and reduced fertility.
      Title: Ack kinase regulates CTP synthase filaments during Drosophila oogenesis.
    2. Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
      Title: Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine.
    3. Data indicate that Activated Cdc42 kinase Ack forms a complex with dreadlocks via its SH2 domain.
      Title: Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis.
    4. We have shown that Ack function can suppress programmed cell death induced by hid or rpr expression in the developing eye and wing discs
      Title: Drosophila activated Cdc42 kinase has an anti-apoptotic function.
    5. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster.
      Title: ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SH2 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to epidermal growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure, amnioserosa morphology change IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in head involution IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myosin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_positive_effect phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoophidium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activated Cdc42 kinase
    Names
    Ack-PA
    CG14992-PA
    NP_647859.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4108186..4114157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139602.3 → NP_647859.1  activated Cdc42 kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647859.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4G3, Q9VZI2
      Related
      FBpp0073067
      Conserved Domains (3) summary
      cd09539
      Location:14 → 75
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14328
      Location:1031 → 1070
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:128 → 385
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRP0 Q8MRP0
    Q9VZI2.2 Q9VZI2

    Gene LinkOut

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