U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG14882 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41994, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG14882provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038429
    Locus tag
    Dmel_CG14882
    See related
    AllianceGenome:FB:FBgn0038429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD10961; Dmel\CG14882
    Summary
    Predicted to enable [methionine synthase] reductase (NADPH) activity. Predicted to be involved in methionine biosynthetic process. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); and homocystinuria. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG14882 in Genome Data Viewer
    Location:
    89B16-89B16; 3-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16443207..16445010)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12268929..12270732)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene endosomal maturation defective Neighboring gene Tetratricopeptide repeat domain 1 Neighboring gene Pak3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster. Matzkin LM, et al. Genetics, 2005 Jul. PMID 15781702, Free PMC Article
    2. Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina. Thanawala SU, et al. Dev Cell, 2013 Apr 15. PMID 23597484, Free PMC Article
    3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    5. A genome-wide resource for the analysis of protein localisation in Drosophila. Sarov M, et al. Elife, 2016 Feb 20. PMID 26896675, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables [methionine synthase] reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG14882-PA
    CG14882-PB
    NP_001262637.1
    NP_650544.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16443207..16445010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275708.1 → NP_001262637.1  uncharacterized protein Dmel_CG14882, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TF6, Q9VEV2
      Conserved Domains (1) summary
      cd06203
      Location:66 → 453
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...

    2. NM_142287.2 → NP_650544.1  uncharacterized protein Dmel_CG14882, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TF6, Q9VEV2
      Related
      FBpp0082740
      Conserved Domains (1) summary
      cd06203
      Location:66 → 453
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TF6 Q95TF6
    Q9VEV2 Q9VEV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools