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    Frq2 Frequenin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32799, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frq2provided by FlyBase
    Official Full Name
    Frequenin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0083228
    Locus tag
    Dmel_CG5907
    See related
    AllianceGenome:FB:FBgn0083228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5907; Dmel\CG5907; dNCS-1; frq; Frq; frq2
    Summary
    Enables calcium ion binding activity. Involved in chemical synaptic transmission; neuromuscular junction development; and regulation of neurotransmitter secretion. Located in cytoplasm. Is expressed in adult head; larval ventral nerve cord; and organism. Orthologous to human NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Frq2 in Genome Data Viewer
    Location:
    17A1-17A2; 1-60 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18177612..18204407)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18071645..18098440)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Frequenin 1 Neighboring gene andorra Neighboring gene HES-related Neighboring gene uncharacterized protein Neighboring gene Holes in muscle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Frq2 from Drosophila melanogaster: cloning, expression, purification, crystallization and preliminary X-ray analysis. Baños-Mateos S, et al. Acta Crystallogr F Struct Biol Commun, 2014 Apr. PMID 24699756, Free PMC Article
    2. Nerve terminal excitability and neuromuscular transmission in T(X;Y)V7 and Shaker mutants of Drosophila melanogaster. Mallart A, et al. J Neurogenet, 1991 Feb. PMID 1851515
    3. Implication of frequenin in the facilitation of transmitter release in Drosophila. Rivosecchi R, et al. J Physiol, 1994 Jan 15. PMID 7911829, Free PMC Article
    4. Modulation of type A K+ current in Drosophila larval muscle by internal Ca2+; effects of the overexpression of frequenin. Poulain C, et al. Pflugers Arch, 1994 May. PMID 8058477
    5. Two frequenins in Drosophila: unveiling the evolutionary history of an unusual neuronal calcium sensor (NCS) duplication. Sánchez-Gracia A, et al. BMC Evol Biol, 2010 Feb 19. PMID 20170488, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Frq modulates Ca(2+) entry through a functional interaction with the alpha(1) voltage-gated Ca(2+)-channel subunit; this interaction regulates neurotransmission and nerve-terminal growth.
      Title: Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth.
    2. Synonymous substitutions have been prevalent in the evolution of the coding region of frq1 and frq2, indicating the presence of strong functional constraints following gene duplication.
      Title: Two frequenins in Drosophila: unveiling the evolutionary history of an unusual neuronal calcium sensor (NCS) duplication.
    3. We conclude that Frqs have two distinct functions: one in neurotransmission, regulating the probability of release per synapse, and another in axonal growth and bouton formation.
      Title: Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium sensitive guanylate cyclase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    frequenin 2
    Names
    CG5907-PA
    CG5907-PB
    CG5907-PC
    CG5907-PD
    Frq2-PA
    Frq2-PB
    Frq2-PC
    Frq2-PD
    frequenin
    neuronal calcium sensor 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18177612..18204407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272746.1 → NP_001259675.1  frequenin 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259675.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWX8
      Conserved Domains (1) summary
      COG5126
      Location:9 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_206778.3 → NP_996501.1  frequenin 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWX8
      Conserved Domains (1) summary
      COG5126
      Location:9 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. NM_080354.4 → NP_525093.1  frequenin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWX8
      Related
      FBpp0074320
      Conserved Domains (1) summary
      COG5126
      Location:9 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. NM_206779.3 → NP_996502.1  frequenin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996502.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWX8
      Conserved Domains (1) summary
      COG5126
      Location:9 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWX8 Q9VWX8
    Q9VWX8.1

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