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    CG1544 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1544provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039827
    Locus tag
    Dmel_CG1544
    See related
    AllianceGenome:FB:FBgn0039827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1544
    Summary
    Predicted to enable 2-oxoadipate dehydrogenase activity. Predicted to be involved in generation of precursor metabolites and energy. Predicted to be located in mitochondrial membrane. Predicted to be part of oxoadipate dehydrogenase complex. Is expressed in adult brain; adult head; adult heart; and adult pars intercerebralis. Used to study Charcot-Marie-Tooth disease axonal type 2Q. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1544 in Genome Data Viewer
    Location:
    100B5-100B5; 3-102 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31196916..31203722)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27022638..27029444)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase beta-subunit at 100B Neighboring gene slow termination of phototransduction Neighboring gene mesh Neighboring gene bottleneck Neighboring gene chaoptin Neighboring gene zwilch

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isoforms of the DHTKD1-Encoded 2-Oxoadipate Dehydrogenase, Identified in Animal Tissues, Are not Observed upon the Human DHTKD1 Expression in Bacterial or Yeast Systems. Boyko AI, et al. Biochemistry (Mosc), 2020 Aug. PMID 33045952
    2. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
    3. Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection. Guzman RM, et al. Genetics, 2021 Mar 31. PMID 33789347, Free PMC Article
    4. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Martelli F, et al. Cell Rep, 2024 Mar 26. PMID 38416643, Free PMC Article
    5. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2-oxoadipate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in generation of precursor metabolites and energy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oxoadipate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1544-PA
    NP_651849.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31196916..31203722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143592.2 → NP_651849.1  uncharacterized protein Dmel_CG1544 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGV6, Q8MT95, Q9VA02, T2FGC6
      Related
      FBpp0085117
      Conserved Domains (4) summary
      PRK09404
      Location:35 → 918
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:178 → 449
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:569 → 772
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16870
      Location:779 → 917
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA02.2 Q9VA02

    Gene LinkOut

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