Elp4 Elongator complex protein 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Elp4provided by FlyBase
Official Full Name: Elongator complex protein 4provided by FlyBase
Primary source: FLYBASE:FBgn0031711
Locus tag: Dmel_CG6907
See related: AllianceGenome:FB:FBgn0031711
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6907; Dmel\CG6907
Summary: Predicted to enable phosphorylase kinase regulator activity. Involved in establishment of mitotic spindle asymmetry. Part of elongator holoenzyme complex. Is expressed in several structures, including anterior endoderm; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human ELP4 (elongator acetyltransferase complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5524139..5525809)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5524139..5525809)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphorylase kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in establishment of mitotic spindle asymmetry	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA wobble uridine modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of elongator holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of elongator holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of elongator holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription elongation factor complex	ISS Inferred from Sequence or Structural Similarity more info