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    Tead3 TEA domain family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 21678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tead3provided by MGI
    Official Full Name
    TEA domain family member 3provided by MGI
    Primary source
    MGI:MGI:109241
    See related
    Ensembl:ENSMUSG00000002249 AllianceGenome:MGI:109241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TEF-5; DTEF-1; ETFR-1; TEAD-3; Tcf13r2
    Summary
    This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in limb E14.5 (RPKM 22.9), bladder adult (RPKM 15.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tead3 in Genome Data Viewer
    Location:
    17 A3.3; 17 14.66 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28550645..28569779, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28331671..28350805, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2476 Neighboring gene Fanconi anemia, complementation group E Neighboring gene ribosomal protein L10A Neighboring gene STARR-seq mESC enhancer starr_42209 Neighboring gene TUB like protein 1 Neighboring gene FK506 binding protein 5 Neighboring gene STARR-seq mESC enhancer starr_42210 Neighboring gene predicted gene, 22146

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Jacquemin P, et al. J Biol Chem, 1997 May 16. PMID 9148898
    2. Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer. Jiang SW, et al. Mol Endocrinol, 1999 Jun. PMID 10379887
    3. Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes. Maeda T, et al. J Biol Chem, 2002 Jul 5. PMID 11986313
    4. A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns. Yasunami M, et al. Biochem Biophys Res Commun, 1996 Nov 12. PMID 8920920
    5. Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells. Cheng Y, et al. Gene Expr Patterns, 2023 Mar. PMID 36516960

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
      Title: Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
    2. Tead transcription factors differentially regulate cortical development.
      Title: Tead transcription factors differentially regulate cortical development.
    3. Experimental evidence for non-AUG translation initiation of human TEF-5. This non-AUG start site, AUA, is conserved in mouse.
      Title: Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer.
    4. DTEF-1 is a target for alpha(1)-adrenergic activation of the skeletal muscle alpha-actin gene in cardiac myocytes
      Title: Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional enhancer factor TEF-5
    Names
    ETF-related factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098226.3 → NP_001091696.2  transcriptional enhancer factor TEF-5 isoform 1

      See identical proteins and their annotated locations for NP_001091696.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). In variants 2 and 3, translation is initiated from an in-frame, downstream, non-AUG (AUA) start site, resulting in a shorter isoform (2).
      Source sequence(s)
      AK087649, CT025652, Y10027
      Consensus CDS
      CCDS50046.1
      UniProtKB/TrEMBL
      F8VPU0, Q8VCA7
      Related
      ENSMUSP00000110447.2, ENSMUST00000114799.8
      Conserved Domains (1) summary
      smart00426
      Location:56 → 123
      TEA; TEA domain

    2. NM_001204156.1 → NP_001191085.1  transcriptional enhancer factor TEF-5 isoform 2

      See identical proteins and their annotated locations for NP_001191085.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has a different 5' terminal exon and initiates translation from an in-frame, downstream, non-AUG (AUA) start site, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
      Source sequence(s)
      CT025652
      Consensus CDS
      CCDS28577.3
      UniProtKB/Swiss-Prot
      O08516, O70623, P70209, P70210
      UniProtKB/TrEMBL
      F6TTJ9
      Related
      ENSMUSP00000118582.3, ENSMUST00000154873.9
      Conserved Domains (1) summary
      smart00426
      Location:30 → 97
      TEA; TEA domain

    3. NM_011566.4 → NP_035696.3  transcriptional enhancer factor TEF-5 isoform 2

      See identical proteins and their annotated locations for NP_035696.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a different 5' terminal exon and initiates translation from an in-frame, downstream, non-AUG (AUA) start site, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
      Source sequence(s)
      CF617964, CT025652, Y10027
      Consensus CDS
      CCDS28577.3
      UniProtKB/Swiss-Prot
      O08516, O70623, P70209, P70210
      UniProtKB/TrEMBL
      F6TTJ9
      Related
      ENSMUSP00000115443.3, ENSMUST00000156862.3
      Conserved Domains (1) summary
      smart00426
      Location:30 → 97
      TEA; TEA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28550645..28569779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70210.2 GenPept UniProtKB/Swiss-Prot:P70210

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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