Ell2 elongation factor for RNA polymerase II 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ell2provided by MGI
Official Full Name: elongation factor for RNA polymerase II 2provided by MGI
Primary source: MGI:MGI:2183438
See related: Ensembl:ENSMUSG00000001542 AllianceGenome:MGI:2183438
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription elongation by RNA polymerase II and snRNA transcription by RNA polymerase II. Predicted to act upstream of or within transcription elongation by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including branchial arch; inner ear; limb bud; limb ectoderm; and maxillary process. Orthologous to human ELL2 (elongation factor for RNA polymerase II 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 25.8), liver E14.5 (RPKM 21.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.93 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (75855603..75920480)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (75707484..75772361)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that ELL2 and its pathway genes likely play an important role in the development and progression of prostate cancer.
Title: Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.
ELL2 is important for many aspects of Ab secretion, XBP1 expression, and the unfolded protein response.
Title: Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Deletion of the Ell2 gene in mice results in loss of Ig secretion from plasma cells and reduced expression of a number of other genes involved in secretion and the unfolded protein response like XBP1, OcaB (BOB1, Pou2af1), cyclin B2 and Ig light chain
Title: Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
The splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secred versus membrane-encoding Ighg2b transcripts at the expense of the secreted isoform.
Title: Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
ELL2 enhanced both polyadenylation and exon skipping with the gene encoding the immunoglobulin heavy-chain complex (Igh) and reporter constructs
Title: Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in snRNA transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in snRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription elongation factor complex	ISO Inferred from Sequence Orthology more info
part_of transcription elongation factor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RNA polymerase II elongation factor ELL2

Names: ELL-related RNA polymerase II, elongation factor; eleven-nineteen lysine-rich leukemia gene 2; elongation factor RNA polymerase II 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138953.2 → NP_620403.2 RNA polymerase II elongation factor ELL2

See identical proteins and their annotated locations for NP_620403.2

Status: VALIDATED

Source sequence(s)

AK145868, BE133837, CT025556

Consensus CDS

CCDS36734.1

UniProtKB/Swiss-Prot

E9QPE1, Q3UKU1

UniProtKB/TrEMBL

B9EKX8

Related

ENSMUSP00000001583.7, ENSMUST00000001583.8

Conserved Domains (2) summary

pfam07303
Location:534 → 631

Occludin_ELL; Occludin homology domain

pfam10390
Location:11 → 289

ELL; RNA polymerase II elongation factor ELL