Bnip1 BCL2/adenovirus E1B interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bnip1provided by MGI
Official Full Name: BCL2/adenovirus E1B interacting protein 1provided by MGI
Primary source: MGI:MGI:109328
See related: Ensembl:ENSMUSG00000024191 AllianceGenome:MGI:109328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sec20; 2010005M06Rik; 5930429G21Rik
Summary: Predicted to enable SNAP receptor activity and calcium-induced calcium release activity. Predicted to be involved in apoptotic process in response to mitochondrial fragmentation; endoplasmic reticulum membrane fusion; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within apoptotic process. Predicted to be located in several cellular components, including COPI-coated vesicle; mitochondrial membrane; and nuclear envelope. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum and mitochondrial outer membrane. Orthologous to human BNIP1 (BCL2 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 6.5), CNS E18 (RPKM 6.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.56 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26999876..27011539)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26781079..26792521)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables calcium-induced calcium release activity	IEA Inferred from Electronic Annotation more info
enables calcium-induced calcium release activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in apoptotic process in response to mitochondrial fragmentation	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process in response to mitochondrial fragmentation	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum membrane fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: vesicle transport protein SEC20

Names: BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP1; BCL2/adenovirus E1B interacting protein 1, NIP1; SNARE protein SEC20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172149.5 → NP_742161.4 vesicle transport protein SEC20

See identical proteins and their annotated locations for NP_742161.4

Status: VALIDATED

Source sequence(s)

AW060311, AY547731, CV560804

Consensus CDS

CCDS28555.1

UniProtKB/Swiss-Prot

B0V2Q1, Q5M9M2, Q6QD59

Related

ENSMUSP00000015725.9, ENSMUST00000015725.16

Conserved Domains (1) summary

cd15865
Location:132 → 224

SNARE_SEC20; SNARE motif of SEC20

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

26999876..27011539

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160513.1 → XP_036016406.1 vesicle transport protein SEC20 isoform X1

UniProtKB/TrEMBL

F6QGF9

Related

ENSMUSP00000116284.2, ENSMUST00000137989.2
XM_030249681.2 → XP_030105541.1 vesicle transport protein SEC20 isoform X2

Conserved Domains (1) summary

cd15865
Location:45 → 137

SNARE_SEC20; SNARE motif of SEC20
XM_036160514.1 → XP_036016407.1 vesicle transport protein SEC20 isoform X2

Conserved Domains (1) summary

cd15865
Location:45 → 137

SNARE_SEC20; SNARE motif of SEC20