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    Nacc2 nucleus accumbens associated 2, BEN and BTB (POZ) domain containing [ Mus musculus (house mouse) ]

    Gene ID: 67991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nacc2provided by MGI
    Official Full Name
    nucleus accumbens associated 2, BEN and BTB (POZ) domain containingprovided by MGI
    Primary source
    MGI:MGI:1915241
    See related
    Ensembl:ENSMUSG00000026932 AllianceGenome:MGI:1915241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Btbd14a; 0610020I02Rik; C030048H19Rik
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Predicted to be located in chromatin; mitochondrion; and nucleolus. Is expressed in several structures, including brain; limb; renal calyx; submandibular gland primordium; and tooth. Orthologous to human NACC2 (NACC family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 26.3), bladder adult (RPKM 17.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nacc2 in Genome Data Viewer
    Location:
    2 A3; 2 18.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25945547..26012823, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26055535..26122811, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1002 Neighboring gene ubiquitin associated domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3363 Neighboring gene STARR-seq mESC enhancer starr_03972 Neighboring gene STARR-seq mESC enhancer starr_03973 Neighboring gene VISTA enhancer mm561 Neighboring gene predicted gene, 54107 Neighboring gene transmembrane protein 250

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Xuan C, et al. Oncogene, 2013 Aug 8. PMID 22926524
    2. A protein interaction network for pluripotency of embryonic stem cells. Wang J, et al. Nature, 2006 Nov 16. PMID 17093407
    3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleus accumbens-associated protein 2
    Names
    BTB (POZ) domain containing 14A
    BTB/POZ domain-containing protein 14A
    NAC-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037098.1 → NP_001032175.1  nucleus accumbens-associated protein 2

      See identical proteins and their annotated locations for NP_001032175.1

      Status: VALIDATED

      Source sequence(s)
      AK147293, AK147310, BE983327, CN668689
      Consensus CDS
      CCDS15796.1
      UniProtKB/Swiss-Prot
      Q3TZD3, Q8VDF8, Q9DCM7
      Related
      ENSMUSP00000109796.3, ENSMUST00000114159.9
      Conserved Domains (3) summary
      smart01025
      Location:371 → 448
      BEN; The BEN domain is found in diverse animal proteins
      cd18289
      Location:1 → 131
      BTB_POZ_BTBD14A_NAC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2)
      pfam02161
      Location:139 → 241
      Prog_receptor; Progesterone receptor

    2. NM_026495.3 → NP_080771.3  nucleus accumbens-associated protein 2

      See identical proteins and their annotated locations for NP_080771.3

      Status: VALIDATED

      Source sequence(s)
      AK147293, CN668689
      Consensus CDS
      CCDS15796.1
      UniProtKB/Swiss-Prot
      Q3TZD3, Q8VDF8, Q9DCM7
      Related
      ENSMUSP00000028300.6, ENSMUST00000028300.6
      Conserved Domains (3) summary
      smart01025
      Location:371 → 448
      BEN; The BEN domain is found in diverse animal proteins
      cd18289
      Location:1 → 131
      BTB_POZ_BTBD14A_NAC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2)
      pfam02161
      Location:139 → 241
      Prog_receptor; Progesterone receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25945547..26012823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498260.1 → XP_006498323.1  nucleus accumbens-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006498323.1

      Conserved Domains (3) summary
      smart01025
      Location:344 → 421
      BEN; The BEN domain is found in diverse animal proteins
      cl38908
      Location:1 → 104
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam02161
      Location:112 → 214
      Prog_receptor; Progesterone receptor

    2. XM_006498259.1 → XP_006498322.1  nucleus accumbens-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006498322.1

      Conserved Domains (3) summary
      smart01025
      Location:344 → 421
      BEN; The BEN domain is found in diverse animal proteins
      cl38908
      Location:1 → 104
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam02161
      Location:112 → 214
      Prog_receptor; Progesterone receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCM7.1 GenPept UniProtKB/Swiss-Prot:Q9DCM7

    Gene LinkOut

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