Eif3m eukaryotic translation initiation factor 3, subunit M [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif3mprovided by MGI
Official Full Name: eukaryotic translation initiation factor 3, subunit Mprovided by MGI
Primary source: MGI:MGI:1351744
See related: Ensembl:ENSMUSG00000027170 AllianceGenome:MGI:1351744
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ga17; Pcid1; Tango7
Summary: Enables translation initiation factor binding activity. Acts upstream of or within translation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in several structures, including central nervous system; liver; metanephros; thymus primordium; and upper jaw tooth. Orthologous to human EIF3M (eukaryotic translation initiation factor 3 subunit M). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 56.9), placenta adult (RPKM 55.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 55.06 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (104830001..104847372, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (104999656..105017027, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

not only is eIF3m an essential gene, but its expression level is also important for mouse embryonic development and the control of organ size.
Title: The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC31799 (e-PCR)
- UniSTS:99841

RH125509 (e-PCR)
- UniSTS:162327

AU040300 (e-PCR)
- UniSTS:158778

NoName (e-PCR)
- UniSTS:491586

AV080665 (e-PCR)
- UniSTS:165186

NoName (e-PCR)
- UniSTS:234079

A002N23 (e-PCR)
- UniSTS:11111

RH124949 (e-PCR)
- UniSTS:161771

RH125431 (e-PCR)
- UniSTS:161771

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit M

Names: PCI domain containing 1 (herpesvirus entry mediator); PCI domain-containing protein 1; dendritic cell protein GA17

NP_663355.1

EC 3.6.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.