Slc25a51 solute carrier family 25, member 51 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a51provided by MGI
Official Full Name: solute carrier family 25, member 51provided by MGI
Primary source: MGI:MGI:2684984
See related: Ensembl:ENSMUSG00000045973 AllianceGenome:MGI:2684984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm138; Mcart1; 9130208E07Rik; D130005A03Rik
Summary: Predicted to enable NAD transmembrane transporter activity. Predicted to be involved in aerobic electron transport chain and mitochondrial NAD transmembrane transport. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to several human genes including SLC25A51 (solute carrier family 25 member 51). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 2.2), liver E14 (RPKM 2.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 23.96 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (45395923..45408922, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (45395923..45408917, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mitochondrial NAD(+) transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions.
Title: The mitochondrial NAD(+) transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions.
The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions in the liver.
Title: The mitochondrial NAD(+) transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions.
SLC25A51 is a mammalian mitochondrial NAD(+) transporter.
Title: SLC25A51 is a mammalian mitochondrial NAD(+) transporter.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables NAD transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aerobic electron transport chain	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial NAD transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial NAD transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

Names: mitochondrial NAD(+) transporter SLC25A51; mitochondrial carrier triple repeat 1; mitochondrial carrier triple repeat protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.