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    Slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 [ Mus musculus (house mouse) ]

    Gene ID: 20523, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a14provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier, brain), member 14provided by MGI
    Primary source
    MGI:MGI:1330823
    See related
    Ensembl:ENSMUSG00000031105 AllianceGenome:MGI:1330823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UCP5; BMCP1; UCP5L; UCP5S
    Summary
    Predicted to enable inorganic anion transmembrane transporter activity; protein homodimerization activity; and proton transmembrane transporter activity. Involved in regulation of cellular response to oxidative stress. Located in mitochondrial envelope. Is expressed in nervous system. Orthologous to human SLC25A14 (solute carrier family 25 member 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 9.8), frontal lobe adult (RPKM 8.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a14 in Genome Data Viewer
    Location:
    X A5; X 25.69 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47712333..47751171)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48623418..48662298)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47122 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene zinc finger protein 280C Neighboring gene G-protein coupled receptor 119 Neighboring gene STARR-seq mESC enhancer starr_47124 Neighboring gene RNA binding motif protein, X-linked 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial proton leak and the uncoupling proteins. Stuart JA, et al. J Bioenerg Biomembr, 1999 Oct. PMID 10653479
    2. Uncoupling protein homologs: emerging views of physiological function. Adams SH. J Nutr, 2000 Apr. PMID 10736318
    3. Uncoupling proteins: a complex journey to function discovery. Cioffi F, et al. Biofactors, 2009 Sep-Oct. PMID 19626697
    4. The role of uncoupling proteins in the regulation of metabolism. Erlanson-Albertsson C. Acta Physiol Scand, 2003 Aug. PMID 12864746
    5. Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle. Lengacher S, et al. J Cereb Blood Flow Metab, 2004 Jul. PMID 15241186

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables solute:inorganic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables solute:inorganic anion antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inorganic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inorganic anion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    brain mitochondrial carrier protein 1
    Names
    mitochondrial uncoupling protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166450.4 → NP_001159922.1  brain mitochondrial carrier protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001159922.1

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      Consensus CDS
      CCDS53066.1
      UniProtKB/Swiss-Prot
      Q9ESI8, Q9Z2B2
      UniProtKB/TrEMBL
      Q8CJ23
      Related
      ENSMUSP00000110586.2, ENSMUST00000114936.8
      Conserved Domains (2) summary
      PTZ00169
      Location:44 → 323
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:234 → 323
      Mito_carr; Mitochondrial carrier protein

    2. NM_001290703.2 → NP_001277632.1  brain mitochondrial carrier protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001277632.1

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      Consensus CDS
      CCDS72376.1
      UniProtKB/TrEMBL
      A0A0A0MQJ8, Q8CJ24
      Conserved Domains (2) summary
      PTZ00169
      Location:9 → 288
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:199 → 288
      Mito_carr; Mitochondrial carrier protein

    3. NM_001290704.2 → NP_001277633.1  brain mitochondrial carrier protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001277633.1

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      Consensus CDS
      CCDS72376.1
      UniProtKB/TrEMBL
      A0A0A0MQJ8, Q8CJ24
      Related
      ENSMUSP00000120332.3, ENSMUST00000134257.8
      Conserved Domains (2) summary
      PTZ00169
      Location:9 → 288
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:199 → 288
      Mito_carr; Mitochondrial carrier protein

    4. NM_001290705.2 → NP_001277634.1  brain mitochondrial carrier protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001277634.1

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      Q8CJ24
      Conserved Domains (2) summary
      PTZ00169
      Location:63 → 342
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:253 → 342
      Mito_carr; Mitochondrial carrier protein

    5. NM_001359136.2 → NP_001346065.1  brain mitochondrial carrier protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      Consensus CDS
      CCDS30112.1
      UniProtKB/TrEMBL
      Q8CJ24
      Conserved Domains (2) summary
      PTZ00169
      Location:41 → 320
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:231 → 320
      Mito_carr; Mitochondrial carrier protein

    6. NM_001403250.1 → NP_001390179.1  brain mitochondrial carrier protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/Swiss-Prot
      Q9ESI8, Q9Z2B2

    7. NM_001403251.1 → NP_001390180.1  brain mitochondrial carrier protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      A0A0A0MQJ8

    8. NM_001403252.1 → NP_001390181.1  brain mitochondrial carrier protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      A0A0A0MQJ8

    9. NM_001403254.1 → NP_001390183.1  brain mitochondrial carrier protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      A0A0A0MQJ8

    10. NM_001403256.1 → NP_001390185.1  brain mitochondrial carrier protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      A0A0A0MQJ8

    11. NM_001403258.1 → NP_001390187.1  brain mitochondrial carrier protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      A0A0A0MQJ8

    12. NM_001403259.1 → NP_001390188.1  brain mitochondrial carrier protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      A0A0A0MQJ8

    13. NM_001403260.1 → NP_001390189.1  brain mitochondrial carrier protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      A0A0A0MQJ8

    14. NM_001403261.1 → NP_001390190.1  brain mitochondrial carrier protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      UniProtKB/TrEMBL
      A0A0A0MQJ8

    15. NM_001403262.1 → NP_001390191.1  brain mitochondrial carrier protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042

    16. NM_001403263.1 → NP_001390192.1  brain mitochondrial carrier protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042

    17. NM_001403264.1 → NP_001390193.1  brain mitochondrial carrier protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042

    18. NM_001403265.1 → NP_001390194.1  brain mitochondrial carrier protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042

    19. NM_011398.4 → NP_035528.1  brain mitochondrial carrier protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_035528.1

      Status: VALIDATED

      Source sequence(s)
      AL669901, AL672042
      Consensus CDS
      CCDS30112.1
      UniProtKB/TrEMBL
      Q8CJ24
      Related
      ENSMUSP00000033431.8, ENSMUST00000033431.14
      Conserved Domains (2) summary
      PTZ00169
      Location:41 → 320
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:231 → 320
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      47712333..47751171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2B2.2 GenPept UniProtKB/Swiss-Prot:Q9Z2B2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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