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    MEH1 Meh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MEH1
    Official Full Name
    Meh1p
    Primary source
    SGD:S000001715
    Locus tag
    YKR007W
    See related
    AllianceGenome:SGD:S000001715; FungiDB:YKR007W; VEuPathDB:YKR007W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EGO1; GSE2
    Summary
    Involved in microautophagy; protein localization to vacuole; and vacuolar acidification. Located in fungal-type vacuole membrane and late endosome membrane. Part of Ragulator complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MEH1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (451434..451988)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein YmL13 Neighboring gene Rsc4p Neighboring gene bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gtr1p differentially associates with Gtr2p and Ego1p. Wang Y, et al. Gene, 2009 May 15. PMID 19374031
    2. Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals. Kogan K, et al. J Mol Biol, 2010 Sep 17. PMID 20655927
    3. ERS1 encodes a functional homologue of the human lysosomal cystine transporter. Gao XD, et al. FEBS J, 2005 May. PMID 15885099
    4. Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1. Zhang T, et al. Structure, 2012 Dec 5. PMID 23123112
    5. Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases. Zhang T, et al. Sci Adv, 2019 Sep. PMID 31579828, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosomal transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of receptor recycling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ragulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ragulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ragulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Meh1p
    NP_012932.1
    • Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; targeted to vacuole via AP-3 pathway; loss results in defect in vacuolar acidification

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      451434..451988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179797.1 → NP_012932.1  TPA: Meh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012932.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX73, Q02205
      UniProtKB/TrEMBL
      A6ZZX2, B3LR91, B5VMF6, C7GQG1, C8ZCH3, N1P2L8
      Conserved Domains (1) summary
      pfam15454
      Location:15 → 92
      LAMTOR; Late endosomal/lysosomal adaptor and MAPK and MTOR activator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02205.1

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