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    MUC3B mucin 3B, cell surface associated [ Homo sapiens (human) ]

    Gene ID: 57876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MUC3Bprovided by HGNC
    Official Full Name
    mucin 3B, cell surface associatedprovided by HGNC
    Primary source
    HGNC:HGNC:13384
    See related
    MIM:605633; AllianceGenome:HGNC:13384
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MUC3; MUC3A
    Summary
    Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: not annotated on reference assembly
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    Genomic context

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    See MUC3B in Genome Data Viewer
    Location:
    7q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102269415..102273580)

    Chromosome 7 - NC_060931.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100546705-100547685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100547686-100548665 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:100548721-100549266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:100551103-100551603 Neighboring gene mucin 3A, cell surface associated Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18473 Neighboring gene mucin-17-like Neighboring gene mucin 12, cell surface associated Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100641457-100642309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100658552-100659220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26396 Neighboring gene Sharpr-MPRA regulatory region 8701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26397 Neighboring gene MUC12 antisense RNA 1 Neighboring gene mucin 17, cell surface associated Neighboring gene RN7SK pseudogene 54

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_060931.1 Chromosome 7 Alternate T2T-CHM13v2.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7. Lang T, et al. PLoS One, 2022. PMID 36256656, Free PMC Article
    2. Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus. Gum JR Jr, et al. J Biol Chem, 2003 Dec 5. PMID 12958310
    3. Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. Kyo K, et al. J Hum Genet, 2001. PMID 11289722
    4. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Pratt WS, et al. Biochem Biophys Res Commun, 2000 Sep 7. PMID 10973822
    5. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Williams SJ, et al. Biochem Biophys Res Commun, 1999 Jul 22. PMID 10405327

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7.
      Title: Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7.
    2. up-regulated MUC expression by synovial tissue cells and suggest a novel role of MUC3 and MUC5AC in the pathogenesis of arthritis
      Title: Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.
    3. has highly conserved amino and carboxyl termini, suggesting a recent duplication of the entire ancestral gene
      Title: Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    mucin-3B
    Names
    MUC-3B
    intestinal mucin MUC3B
    intestinal mucin-3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      102269415..102273580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444977.1 → XP_047300933.1  mucin-3B

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H195.3 GenPept UniProtKB/Swiss-Prot:Q9H195

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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