S1PR5 sphingosine-1-phosphate receptor 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: S1PR5provided by HGNC
Official Full Name: sphingosine-1-phosphate receptor 5provided by HGNC
Primary source: HGNC:HGNC:14299
See related: Ensembl:ENSG00000180739 MIM:605146; AllianceGenome:HGNC:14299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EDG8; S1P5; Edg-8; SPPR-1; SPPR-2
Summary: The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Expression: Biased expression in skin (RPKM 5.9), bone marrow (RPKM 5.0) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (10512742..10517965, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (10639179..10644407, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (10623418..10628641, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P5 in live cells.
Title: Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P(5) in live cells.
our findings establish that S1PR5 is of central importance for human NK-cell response to sphingosine-1-phosphate and suggest that it is required for their egress from the bone marrow and secondary lymphoid organs.
Title: S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate.
Reduced DNA methylation may underlie the increased expression of the S1PR5 gene in alveolar macrophages and associated defective efferocytosis in COPD.
Title: Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.
Data indicate that the mitotic kinase Polo-like kinase 1 (PLK1) was an important effector of S1P-S1P5 signaling, and a new function of the SphK1-S1P pathway specifically in the control of mitosis in HeLa cells.
Title: Sphingosine 1-phosphate signaling through its receptor S1P(5) promotes chromosome segregation and mitotic progression.
TGF-beta2 dependent upregulation of S1P5 is required for the induction of pro-fibrotic CTGF by TGF-beta in mesangial cells.
Title: Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.
This report is the first to demonstrate a reduction in S1P5 in multiple sclerosis lesions, which parallels that of myelin loss.
Title: Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions.
Data show that sphingosine kinase SphK1 and sphingosine-1-phosphate (S1P) receptors S1P1, S1P2, S1P3, and S1P5 were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 levels were highest in primary tumors.
Title: The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.
Edg-5 receptor in brain endothelial cells contributes to optimal barrier formation and maintenance of immune quiescence of the barrier endothelium.
Title: Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier.
The decreased expression level of S1PR5 on NK cells is associated with graft versus host disease occurrence after allogeneic hematopoietic stem cell transplantation.
Title: [Influence of NK cell S1PR5 expression on graft versus host disease in allogeneic hematopoietic stem cell transplantation].
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A genome-wide study reveals copy number variants exclusive to childhood obesity cases.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78976 (e-PCR)
- UniSTS:67669

SHGC-53359 (e-PCR)
- UniSTS:30847

Edg8 (e-PCR), detects polymorphism
- UniSTS:496527

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sphingosine-1-phosphate receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 5

Names: S1P receptor 5; S1P receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; sphingosine 1-phosphate receptor EDG8; sphingosine 1-phosphate receptor Edg-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166215.2 → NP_001159687.1 sphingosine 1-phosphate receptor 5

See identical proteins and their annotated locations for NP_001159687.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC011461, AF331840, BC034703, DA866378, DB013424

Consensus CDS

CCDS12240.1

UniProtKB/Swiss-Prot

Q6NW11, Q9H228

Related

ENSP00000416915.2, ENST00000439028.3

Conserved Domains (1) summary

cd15348
Location:37 → 317

7tmA_S1PR5_Edg8; sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors
NM_030760.5 → NP_110387.1 sphingosine 1-phosphate receptor 5

See identical proteins and their annotated locations for NP_110387.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC011461, AF331840, BC034703, DA747912

Consensus CDS

CCDS12240.1

UniProtKB/Swiss-Prot

Q6NW11, Q9H228

Related

ENSP00000328472.3, ENST00000333430.6

Conserved Domains (1) summary

cd15348
Location:37 → 317

7tmA_S1PR5_Edg8; sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors