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    Upb1 beta-ureidopropionase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116593, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Upb1provided by RGD
    Official Full Name
    beta-ureidopropionase 1provided by RGD
    Primary source
    RGD:620091
    See related
    EnsemblRapid:ENSRNOG00000038258 AllianceGenome:RGD:620091
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bup1
    Summary
    Enables beta-ureidopropionase activity and zinc ion binding activity. Involved in beta-alanine metabolic process; in utero embryonic development; and liver development. Predicted to be active in cytosol. Orthologous to human UPB1 (beta-ureidopropionase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1843.4) and Kidney (RPKM 807.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Upb1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (13216693..13243016, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (13217252..13243590, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (14167383..14193724, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556392 Neighboring gene microRNA 327 Neighboring gene uncharacterized LOC102556333 Neighboring gene uncharacterized LOC134483891 Neighboring gene uncharacterized LOC134483785 Neighboring gene uncharacterized LOC120098899 Neighboring gene adenosine A2a receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Capacity of rat liver for pyrimidine synthesis and catabolism during fetal and neonatal development. Hardiman MK, et al. Arch Biochem Biophys, 1983 Jul 1. PMID 6870258
    2. Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism. Maurer D, et al. Biochem J, 2018 Jul 31. PMID 29976570
    3. Cloning, sequencing, and expression of a cDNA encoding beta-alanine synthase from rat liver. Kvalnes-Krick KL, et al. J Biol Chem, 1993 Mar 15. PMID 8449931
    4. ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients. van Kuilenburg AB, et al. Biochim Biophys Acta, 2012 Jul. PMID 22525402
    5. beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities. van Kuilenburg AB, et al. Hum Mol Genet, 2004 Nov 15. PMID 15385443

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-ureidopropionase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-ureidopropionase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-ureidopropionase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in beta-alanine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in beta-alanine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dCMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in in utero embryonic development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in liver development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleoside catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-ureidopropionase
    Names
    N-carbamoyl-beta-alanine amidohydrolase
    beta-alanine synthase
    ureidopropionase, beta
    NP_446297.1
    XP_038954314.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053845.2 → NP_446297.1  beta-ureidopropionase

      See identical proteins and their annotated locations for NP_446297.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q03248
      UniProtKB/TrEMBL
      D3Z8J1
      Related
      ENSRNOP00000092718.1, ENSRNOT00000115726.2
      Conserved Domains (1) summary
      cd07587
      Location:9 → 371
      ML_beta-AS; mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      13216693..13243016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098386.2 → XP_038954314.1  beta-ureidopropionase isoform X1

      Conserved Domains (1) summary
      cl11424
      Location:1 → 212
      nitrilase; Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03248.1 GenPept UniProtKB/Swiss-Prot:Q03248

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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