CUP9 Cup9p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CUP9
Official Full Name: Cup9p
Primary source: SGD:S000006098
Locus tag: YPL177C
See related: AllianceGenome:SGD:S000006098; FungiDB:YPL177C; VEuPathDB:YPL177C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of dipeptide transport and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Used to study Down syndrome; cancer (multiple); restless legs syndrome; and substance dependence. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; cleft palate, cardiac defects, and intellectual disabillity; holoprosencephaly (multiple); orofacial cleft (multiple); and restless legs syndrome. Orthologous to several human genes including MEIS1 (Meis homeobox 1); MEIS2 (Meis homeobox 2); and MEIS3 (Meis homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of dipeptide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oligopeptide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_015148.1

Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress