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    INN1 Inn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855570, updated on 9-Dec-2024

    Summary

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    Official Symbol
    INN1
    Official Full Name
    Inn1p
    Primary source
    SGD:S000005096
    Locus tag
    YNL152W
    See related
    AllianceGenome:SGD:S000005096; FungiDB:YNL152W; VEuPathDB:YNL152W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme regulator activity. Involved in chromosome organization and secondary cell septum biogenesis. Located in cellular bud neck contractile ring. Part of HICS complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See INN1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (346313..347542)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase YCK2 Neighboring gene tubulin-binding prefolding complex subunit GIM3 Neighboring gene DNA-directed RNA polymerase III subunit C31 Neighboring gene Pga2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Sanchez-Diaz A, et al. Nat Cell Biol, 2008 Apr. PMID 18344988
    2. Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts. Devrekanli A, et al. J Cell Sci, 2012 Nov 15. PMID 22956544
    3. Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. Wang M, et al. Mol Biol Cell, 2018 Mar 1. PMID 29321253, Free PMC Article
    4. Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck. Jendretzki A, et al. Mol Genet Genomics, 2009 Oct. PMID 19707790
    5. Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast. Nkosi PJ, et al. PLoS One, 2013. PMID 23469085, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a new and widely applicable tool to generate conditionally phosphorylated proteins to identify those whose dephosphorylation is required for cytokinesis. This approach identifies Aip1, Ede1 and Inn1 as cytokinetic regulators.
      Title: Identification of Cdk targets that control cytokinesis.
    2. Dephosphorylation of Inn1 is important for its function in promoting cytokinesis.
      Title: Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation.
    3. Cyk3 is part of an actomyosin ring independent cytokinesis pathway, which acts as a rescue mechanism to recruit Inn1 to the bud neck.
      Title: Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck.
    4. Data show that the Inn1 C-terminal region is necessary for localization, and distinct PXXP motifs in this region mediate functionally important interactions with SH3 domains in the cytokinesis proteins Hof1 and Cyk3.
      Title: Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.
    5. Data indicate that recruitment of the C2 domain of Inn1 to the contractile actomyosin ring is crucial for ingression of the plasma membrane during cytokinesis in budding yeast.
      Title: Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secondary cell septum biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in secondary cell septum biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HICS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Inn1p
    NP_014247.1
    • Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      346313..347542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182990.1 → NP_014247.1  TPA: Inn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014247.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W131, P53901, Q6Q5J6
      UniProtKB/TrEMBL
      B3LP07, C7GXV2, C8ZG76, N1NZA7
      Conserved Domains (1) summary
      cd08681
      Location:11 → 133
      C2_fungal_Inn1p-like; C2 domain found in fungal Ingression 1 (Inn1) proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53901.1

    Gene LinkOut

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