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    Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 74763, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Naa60provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 60, NatF catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1922013
    See related
    Ensembl:ENSMUSG00000005982 AllianceGenome:MGI:1922013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HAT4; NatF; Nat15; 1200013P24Rik
    Summary
    Predicted to enable histone H4 acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and protein homodimerization activity. Predicted to be involved in several processes, including N-terminal peptidyl-methionine acetylation; chromosome segregation; and nucleosome assembly. Predicted to be active in Golgi membrane. Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 39.1), mammary gland adult (RPKM 28.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Naa60 in Genome Data Viewer
    Location:
    16 A1; 16 2.28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3690365..3722645)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (3872496..3904781)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39909 Neighboring gene predicted gene, 41409 Neighboring gene STARR-seq mESC enhancer starr_39910 Neighboring gene STARR-positive B cell enhancer ABC_E5522 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene zinc finger protein 174 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872304-3872526 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872697-3872880 Neighboring gene zinc finger protein 597 Neighboring gene STARR-positive B cell enhancer mm9_chr16:3884448-3884748 Neighboring gene RIKEN cDNA 1700037C18 gene Neighboring gene predicted gene, 41410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3908535-3908837 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3909019-3909128 Neighboring gene clusterin associated protein 1 Neighboring gene prothymosin alpha-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide-methionine-alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-methionine acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal protein amino acid acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 60
    Names
    N-acetyltransferase 15 (GCN5-related, putative)
    N-alpha-acetyltransferase F
    histone acetyltransferase type B protein 4
    natF catalytic subunit
    NP_001277618.1
    NP_083366.1
    XP_006522742.1
    XP_006522743.1
    XP_017172644.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290689.1 → NP_001277618.1  N-alpha-acetyltransferase 60 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC129021, AI035720, AI448494, AK004750
      Consensus CDS
      CCDS70676.1
      UniProtKB/TrEMBL
      H3BIY0
      Related
      ENSMUSP00000134768.2, ENSMUST00000176625.8
      Conserved Domains (2) summary
      pfam00583
      Location:12 → 90
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:74 → 138
      TIM; TIM-like beta/alpha barrel domains

    2. NM_029090.3 → NP_083366.1  N-alpha-acetyltransferase 60 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC129021, BG147816, BI739241, BY255312, CF540715
      Consensus CDS
      CCDS37239.1
      UniProtKB/Swiss-Prot
      Q9DBU2
      Related
      ENSMUSP00000140031.2, ENSMUST00000186375.8
      Conserved Domains (2) summary
      pfam00583
      Location:23 → 155
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:139 → 203
      TIM; TIM-like beta/alpha barrel domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      3690365..3722645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522680.4 → XP_006522743.1  N-alpha-acetyltransferase 60 isoform X1

      UniProtKB/Swiss-Prot
      Q9DBU2
      Related
      ENSMUSP00000135206.2, ENSMUST00000150655.3
      Conserved Domains (2) summary
      pfam00583
      Location:23 → 155
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:139 → 203
      TIM; TIM-like beta/alpha barrel domains

    2. XM_017317155.2 → XP_017172644.1  N-alpha-acetyltransferase 60 isoform X2

      UniProtKB/TrEMBL
      H3BJZ6
      Related
      ENSMUSP00000135188.2, ENSMUST00000143537.9
      Conserved Domains (1) summary
      cl17182
      Location:23 → 113
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    3. XM_006522679.3 → XP_006522742.1  N-alpha-acetyltransferase 60 isoform X1

      UniProtKB/Swiss-Prot
      Q9DBU2
      Conserved Domains (2) summary
      pfam00583
      Location:23 → 155
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:139 → 203
      TIM; TIM-like beta/alpha barrel domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBU2.1 GenPept UniProtKB/Swiss-Prot:Q9DBU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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