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    CRG1 S-adenosylmethionine-dependent methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CRG1
    Official Full Name
    S-adenosylmethionine-dependent methyltransferase
    Primary source
    SGD:S000001252
    Locus tag
    YHR209W
    See related
    AllianceGenome:SGD:S000001252; FungiDB:YHR209W; VEuPathDB:YHR209W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables S-adenosylmethionine-dependent methyltransferase activity and mRNA binding activity. Involved in lipid homeostasis. Predicted to be located in cytoplasm. Orthologous to human TMT1A (thiol methyltransferase 1A) and TMT1B (thiol methyltransferase 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CRG1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (519437..520312)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene branched-chain-amino-acid transaminase BAT1 Neighboring gene aldose 1-epimerase superfamily protein Neighboring gene flocculin FLO5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Crg1 N-Terminus Is Essential for Methyltransferase Activity and Cantharidin Resistance in Saccharomyces cerevisiae. Sahu PK, et al. Biochemistry, 2019 Apr 2. PMID 30830767
    2. An integrated platform of genomic assays reveals small-molecule bioactivities. Hoon S, et al. Nat Chem Biol, 2008 Aug. PMID 18622389
    3. An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae. Wilkening S, et al. Genetics, 2014 Mar. PMID 24374355, Free PMC Article
    4. Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design. Smith JD, et al. Genome Biol, 2016 Mar 8. PMID 26956608, Free PMC Article
    5. S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase. Niewmierzycka A, et al. J Biol Chem, 1999 Jan 8. PMID 9873020

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylmethionine-dependent methyltransferase
    NP_012079.1
    • S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      519437..520312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179340.1 → NP_012079.1  TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLF8, P38892, Q6Q5R3
      UniProtKB/TrEMBL
      A6ZTB6, B3LSX0, C7GN94, C8ZA10, G2WFT3, N1P1D6
      Conserved Domains (1) summary
      pfam08241
      Location:43 → 140
      Methyltransf_11; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38892.1

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