Krt14 keratin 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt14provided by MGI
Official Full Name: keratin 14provided by MGI
Primary source: MGI:MGI:96688
See related: Ensembl:ENSMUSG00000045545 AllianceGenome:MGI:96688
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K14; CK-14; Krt1-14; Krt-1.14
Summary: This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Biased expression in stomach adult (RPKM 89.1), limb E14.5 (RPKM 80.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 63.43 cM; 11 D

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100093988..100098336, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100203162..100207510, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.
Title: In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.
Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
Title: Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.
Title: Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.
Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3sigma and YAP1.
Title: Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1.
Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
Title: Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
keratin 1 (K1) is essential for the persistent infection caused by LCMV strain MX, and its absence very effectively slows down the course of infection
Title: Absence of keratin 1 restricts the course of infection with lymphocytic choriomeningitis virus strain MX.
Cumulatively, these data indicate that altered CK14 (high) and CK18 (low) expression is perhaps an early event in bladder cancer tumorigenesis in females at least and is characteristic of both urothelial superficial pre-neoplastic and neoplastic lesions.
Title: Differential expression of cytokeratin 14 and 18 in bladder cancer tumorigenesis.
KRT14 is expressed in a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.
Title: KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.
CDK1, Aurora-B, and Rho-kinase phosphorylate keratin 5/14.
Title: Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.
RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling.
Title: Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10) 1 citation
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G16019 (e-PCR)
- UniSTS:78871

AI626930 (e-PCR)
- UniSTS:185915

Krt1-14 (e-PCR), detects polymorphism
- UniSTS:143737

Krt16 (e-PCR), detects polymorphism
- UniSTS:547450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables keratin filament binding	IEA Inferred from Electronic Annotation more info
enables keratin filament binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hair cycle	IEA Inferred from Electronic Annotation more info
involved_in hair cycle	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to radiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 14

Names: cytokeratin 14; keratin complex 1, acidic, gene 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313956.1 → NP_001300885.1 keratin, type I cytoskeletal 14 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AA050376, AA562488, AA612291, AI893364, AL590873

Conserved Domains (2) summary

pfam00038
Location:120 → 370

Filament; Intermediate filament protein

cl19219
Location:235 → 345

DUF342; Protein of unknown function (DUF342)
NM_001313957.1 → NP_001300886.1 keratin, type I cytoskeletal 14 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (3) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AA499338, AA562488, AA612291, AA760592, AI893364, AL590873

UniProtKB/Swiss-Prot

Q61781

Related

ENSMUST00000137265.2

Conserved Domains (1) summary

pfam00038
Location:1 → 214

Filament; Intermediate filament protein
NM_016958.2 → NP_058654.1 keratin, type I cytoskeletal 14 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA499338, AA562488, AA612291, AA760592, AI893364, AL590873

Consensus CDS

CCDS25413.1

UniProtKB/Swiss-Prot

A2A4G4, Q61781, Q91VQ4, Q99LE0

Related

ENSMUSP00000007272.8, ENSMUST00000007272.8

Conserved Domains (1) summary

pfam00038
Location:120 → 431

Filament; Intermediate filament protein