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    APL5 Apl5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APL5
    Official Full Name
    Apl5p
    Primary source
    SGD:S000006116
    Locus tag
    YPL195W
    See related
    AllianceGenome:SGD:S000006116; FungiDB:YPL195W; VEuPathDB:YPL195W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKS4
    Summary
    Involved in Golgi to vacuole transport and protein targeting to vacuole. Part of AP-3 adaptor complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Orthologous to human AP3D1 (adaptor related protein complex 3 subunit delta 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APL5 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (176223..179021)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L7B Neighboring gene ncRNA Neighboring gene Oxr1p Neighboring gene Ddc1p Neighboring gene Rsa1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains. Darsow T, et al. Mol Biol Cell, 2001 Jan. PMID 11160821, Free PMC Article
    2. Proteins required for vacuolar function are targets of lysine polyphosphorylation in yeast. McCarthy L, et al. FEBS Lett, 2020 Jan. PMID 31466120
    3. Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein. Wen W, et al. Mol Biol Cell, 2006 Oct. PMID 16855025, Free PMC Article
    4. Organelle size scaling of the budding yeast vacuole is tuned by membrane trafficking rates. Chan YH, et al. Biophys J, 2014 May 6. PMID 24806931, Free PMC Article
    5. Mutational analysis of the yeast TRAPP subunit Trs20p identifies roles in endocytic recycling and sporulation. Mahfouz H, et al. PLoS One, 2012. PMID 23049729, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-3 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of AP-3 adaptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apl5p
    NP_015129.1
    • Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      176223..179021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184009.1 → NP_015129.1  TPA: Apl5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3H3, Q02737, Q08951, Q7LIB1
      UniProtKB/TrEMBL
      A6ZW58, B3LKN3, C8ZII4, N1NXZ6
      Conserved Domains (1) summary
      pfam01602
      Location:45 → 610
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08951.1

    Gene LinkOut

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