Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3c3provided by MGI
Official Full Name: phosphatidylinositol 3-kinase catalytic subunit type 3provided by MGI
Primary source: MGI:MGI:2445019
See related: Ensembl:ENSMUSG00000033628 AllianceGenome:MGI:2445019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vps34; 5330434F23Rik
Summary: Enables protein kinase activity. Involved in cellular response to glucose starvation; macroautophagy; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including phosphatidylinositol-3-phosphate biosynthetic process; protein localization to phagophore assembly site; and protein phosphorylation. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is active in GABA-ergic synapse; endosome; and glutamatergic synapse. Is expressed in several structures, including Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E14 (RPKM 15.0), CNS E18 (RPKM 11.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 17.41 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (30390441..30481179)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (30265615..30348126)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis.
Title: Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis.
Pik3c3 expression profiling in the mouse kidney and its role in proximal tubule cell physiology.
Title: Pik3c3 expression profiling in the mouse kidney and its role in proximal tubule cell physiology.
Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence.
Title: Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence.
Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).
Title: Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).
PIK3C3/VPS34 helps school T cells in the thymus.
Title: PIK3C3/VPS34 helps school T cells in the thymus.
Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases.
Title: Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases.
Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection.
Title: Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection.
Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis.
Title: Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis.
Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1beta production.
Title: Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production.
Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy.
Title: Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol kinase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol-3-phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation by host of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein lipidation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein localization to phagophore assembly site	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	EXP Inferred from Experiment more info	PubMed
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in autolysosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in autophagosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class III	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endosome	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic endosome	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3-kinase catalytic subunit type 3

Names: PI3-kinase type 3; PI3K type 3; phosphoinositide-3-kinase, class 3; ptdIns-3-kinase type 3

NP_852079.2

EC 2.7.1.137

XP_030106284.1

EC 2.7.1.137

XP_030106285.1

EC 2.7.1.137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181414.6 → NP_852079.2 phosphatidylinositol 3-kinase catalytic subunit type 3

See identical proteins and their annotated locations for NP_852079.2

Status: VALIDATED

Source sequence(s)

AC163399, AK044997, BE950444, BE980562

Consensus CDS

CCDS37752.1

UniProtKB/Swiss-Prot

Q6PF93, Q8R3S8

UniProtKB/TrEMBL

E9QLS6

Related

ENSMUSP00000111479.4, ENSMUST00000115812.10

Conserved Domains (3) summary

cd08397
Location:26 → 186

C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)

cd00870
Location:283 → 503

PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...

cd00896
Location:539 → 883

PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RNA

NR_151699.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC163399, BE980562

Related

ENSMUST00000131405.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

30390441..30481179

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250425.2 → XP_030106285.1 phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

UniProtKB/Swiss-Prot

Q6PF93, Q8R3S8

UniProtKB/TrEMBL

E9QLS6

Conserved Domains (3) summary

cd08397
Location:26 → 186

C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)

cd00870
Location:283 → 503

PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...

cd00896
Location:539 → 883

PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase
XM_030250424.1 → XP_030106284.1 phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

UniProtKB/Swiss-Prot

Q6PF93, Q8R3S8

UniProtKB/TrEMBL

E9QLS6

Conserved Domains (3) summary

cd08397
Location:26 → 186

C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)

cd00870
Location:283 → 503

PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...

cd00896
Location:539 → 883

PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase