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    Mak16 MAK16 homolog [ Mus musculus (house mouse) ]

    Gene ID: 67920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mak16provided by MGI
    Official Full Name
    MAK16 homologprovided by MGI
    Primary source
    MGI:MGI:1915170
    See related
    Ensembl:ENSMUSG00000031578 AllianceGenome:MGI:1915170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbm13; 2600016B03Rik
    Summary
    Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; jaw; sensory organ; and thymus primordium. Orthologous to human MAK16 (MAK16 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 19.0), liver E14 (RPKM 12.7) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mak16 in Genome Data Viewer
    Location:
    8 A3; 8 18.05 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (31649496..31658752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31159468..31168724, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4995 Neighboring gene STARR-positive B cell enhancer ABC_E2861 Neighboring gene ring finger protein 122 Neighboring gene STARR-positive B cell enhancer ABC_E557 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene TELO2 interacting protein 2 Neighboring gene fucosyltransferase 10 Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein MAK16 homolog
    Names
    RNA binding motif protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026453.3 → NP_080729.1  protein MAK16 homolog

      See identical proteins and their annotated locations for NP_080729.1

      Status: VALIDATED

      Source sequence(s)
      AC109163
      Consensus CDS
      CCDS22222.1
      UniProtKB/Swiss-Prot
      Q8BGS0, Q921E0, Q9D5G6
      Related
      ENSMUSP00000033983.5, ENSMUST00000033983.6
      Conserved Domains (3) summary
      COG5129
      Location:2 → 288
      MAK16; Nuclear protein with HMG-like acidic region [General function prediction only]
      pfam01778
      Location:6 → 116
      Ribosomal_L28e; Ribosomal L28e protein family
      pfam04874
      Location:148 → 194
      Mak16; Mak16 protein C-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      31649496..31658752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGS0.1 GenPept UniProtKB/Swiss-Prot:Q8BGS0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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