Btg4 BTG anti-proliferation factor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Btg4provided by MGI
Official Full Name: BTG anti-proliferation factor 4provided by MGI
Primary source: MGI:MGI:1860140
See related: Ensembl:ENSMUSG00000032056 AllianceGenome:MGI:1860140
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PC3B
Summary: Enables mRNA 3'-UTR binding activity. Acts upstream of or within maternal-to-zygotic transition of gene expression and negative regulation of mitotic cell cycle. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; early embryo; gonad; nasal cavity epithelium; and retina. Orthologous to human BTG4 (BTG anti-proliferation factor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 2.3) See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.84 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (51013486..51031224)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (51102147..51119924)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bioinformatic analysis of the clinicopathological and prognostic significance of oocyte-arresting BTG4 mRNA expression in gynecological cancers.
Title: Bioinformatic analysis of the clinicopathological and prognostic significance of oocyte-arresting BTG4 mRNA expression in gynecological cancers.
Using the 3'-UTRs of mouse Cpeb1, Btg4 and Cnot6l mRNAs, we deciphered the combinatorial code that controls developmental stage-specific translation during meiotic maturation
Title: A combinatorial code for mRNA 3'-UTR-mediated translational control in the mouse oocyte.
BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis
Title: BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis.
The intrinsic MAP kinase cascade in oocytes triggered translation of Btg4 mRNA stored in fully grown oocytes by targeting the 3' untranslated region, thereby coupling CCR4-NOT deadenylase-mediated decay of maternal mRNA with oocyte maturation and fertilization.
Title: BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.
study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
Title: The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.
IF5/BTG4 may be an aging-related gene in epithelial cells
Title: Age-related decrease of IF5/BTG4 in oral and respiratory cavities in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236124

RH127262 (e-PCR)
- UniSTS:208378

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within maternal-to-zygotic transition of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein BTG4

Names: B cell translocation gene 4; BTG family member 4; protein PC3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.