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    Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501546, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Huwe1provided by RGD
    Official Full Name
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by RGD
    Primary source
    RGD:1561763
    See related
    EnsemblRapid:ENSRNOG00000061262 AllianceGenome:RGD:1561763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    URE-B1
    Summary
    Enables DNA binding activity. Predicted to be involved in several processes, including circadian regulation of gene expression; negative regulation of mitochondrial fusion; and protein ubiquitination. Located in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 342.2), Kidney (RPKM 310.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Huwe1 in Genome Data Viewer
    Location:
    Xq13
    Exon count:
    90
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (24350708..24480798)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (20873795..21001378)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (21474627..21603348)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484046 Neighboring gene AKT serine/threonine kinase 2, pseudogene 1 Neighboring gene ribosomal protein S9, pseudogene 3 Neighboring gene microRNA let-7f-2 Neighboring gene microRNA 98 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 10 Neighboring gene RIB43A domain with coiled-coils 1 Neighboring gene structural maintenance of chromosomes 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation. Gu J, et al. Oncogene, 1995 Nov 16. PMID 7478539
    2. Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells. He GQ, et al. Mol Brain, 2015 Dec 23. PMID 26698301, Free PMC Article
    3. Huwe1 is a novel mediator of protection of neural progenitor L2.3 cells against oxygen‑glucose deprivation injury. Jiang X, et al. Mol Med Rep, 2018 Nov. PMID 30221657
    4. Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene. Gu J, et al. Brain Res Mol Brain Res, 1994 Jul. PMID 7968380
    5. Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones. Liu Z, et al. Mol Cell Biol, 2005 Apr. PMID 15767685, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone ubiquitin ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in base-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of type 2 mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branched polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HUWE1
    Names
    HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
    HECT, UBA and WWE domain-containing protein 1
    HECT-type E3 ubiquitin transferase HUWE1
    URE-binding protein 1
    upstream regulatory element-binding protein 1
    NP_001395856.1
    XP_063136267.1
    XP_063136268.1
    XP_063136269.1
    XP_063136270.1
    XP_063136271.1
    XP_063136272.1
    XP_063136273.1
    XP_063136274.1
    XP_063136275.1
    XP_063136276.1
    XP_063136277.1
    XP_063136278.1
    XP_063136279.1
    XP_063136280.1
    XP_063136281.1
    XP_063136282.1
    XP_063136283.1
    XP_063136284.1
    XP_063136285.1
    XP_063136286.1
    XP_063136287.1
    XP_063136288.1
    XP_063136289.1
    XP_063136290.1
    XP_063136291.1
    XP_063136292.1
    XP_063136293.1
    XP_063136294.1
    XP_063136295.1
    XP_063136296.1
    XP_063136297.1
    XP_063136298.1
    XP_063136299.1
    XP_063136300.1
    XP_063136301.1
    XP_063136302.1
    XP_063136303.1
    XP_063136304.1
    XP_063136305.1
    XP_063136306.1
    XP_063136307.1
    XP_063136308.1
    XP_063136309.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408927.1 → NP_001395856.1  E3 ubiquitin-protein ligase HUWE1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A634
      Related
      ENSRNOP00000088915.1, ENSRNOT00000109386.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      24350708..24480798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280233.1 → XP_063136303.1  E3 ubiquitin-protein ligase HUWE1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A634

    2. XM_063280199.1 → XP_063136269.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    3. XM_063280222.1 → XP_063136292.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593

    4. XM_063280208.1 → XP_063136278.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    5. XM_063280232.1 → XP_063136302.1  E3 ubiquitin-protein ligase HUWE1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A634
      Related
      ENSRNOP00000069644.3, ENSRNOT00000081037.3

    6. XM_063280209.1 → XP_063136279.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    7. XM_063280198.1 → XP_063136268.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    8. XM_063280216.1 → XP_063136286.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593

    9. XM_063280204.1 → XP_063136274.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    10. XM_063280217.1 → XP_063136287.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593

    11. XM_063280230.1 → XP_063136300.1  E3 ubiquitin-protein ligase HUWE1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A634

    12. XM_063280207.1 → XP_063136277.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    13. XM_063280202.1 → XP_063136272.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    14. XM_063280218.1 → XP_063136288.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593

    15. XM_063280205.1 → XP_063136275.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    16. XM_063280201.1 → XP_063136271.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    17. XM_063280215.1 → XP_063136285.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593

    18. XM_063280206.1 → XP_063136276.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    19. XM_063280221.1 → XP_063136291.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593

    20. XM_063280231.1 → XP_063136301.1  E3 ubiquitin-protein ligase HUWE1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A634

    21. XM_063280200.1 → XP_063136270.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    22. XM_063280220.1 → XP_063136290.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593

    23. XM_063280228.1 → XP_063136298.1  E3 ubiquitin-protein ligase HUWE1 isoform X12

    24. XM_063280197.1 → XP_063136267.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    25. XM_063280210.1 → XP_063136280.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

    26. XM_063280225.1 → XP_063136295.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

    27. XM_063280226.1 → XP_063136296.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

    28. XM_063280227.1 → XP_063136297.1  E3 ubiquitin-protein ligase HUWE1 isoform X11

    29. XM_063280235.1 → XP_063136305.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      Related
      ENSRNOP00000071818.3, ENSRNOT00000090890.3

    30. XM_063280211.1 → XP_063136281.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    31. XM_063280212.1 → XP_063136282.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

    32. XM_063280213.1 → XP_063136283.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

    33. XM_063280223.1 → XP_063136293.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    34. XM_063280237.1 → XP_063136307.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

    35. XM_063280224.1 → XP_063136294.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

    36. XM_063280229.1 → XP_063136299.1  E3 ubiquitin-protein ligase HUWE1 isoform X13

    37. XM_063280214.1 → XP_063136284.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593
      Related
      ENSRNOP00000095129.1, ENSRNOT00000098599.2

    38. XM_063280239.1 → XP_063136309.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

    39. XM_063280236.1 → XP_063136306.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    40. XM_063280234.1 → XP_063136304.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

    41. XM_063280238.1 → XP_063136308.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

    42. XM_063280203.1 → XP_063136273.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    43. XM_063280219.1 → XP_063136289.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A0A8I6APS3, P51593
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51593.3 GenPept UniProtKB/Swiss-Prot:P51593

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