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    IAH1 isoamyl acetate-hydrolyzing esterase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IAH1
    Official Full Name
    isoamyl acetate-hydrolyzing esterase
    Primary source
    SGD:S000005652
    Locus tag
    YOR126C
    See related
    AllianceGenome:SGD:S000005652; FungiDB:YOR126C; VEuPathDB:YOR126C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables hydrolase activity, acting on ester bonds. Involved in acetate metabolic process. Orthologous to human IAH1 (isoamyl acetate hydrolyzing esterase 1 (putative)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IAH1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (559961..560677, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP2 Neighboring gene putative monooxygenase CAT5 Neighboring gene GTPase-activating protein RGA1 Neighboring gene phosphoribosylaminoimidazole carboxylase ADE2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of isoamyl acetate-hydrolyzing esterase encoded by the IAH1 gene of Saccharomyces cerevisiae from a recombinant Escherichia coli. Fukuda K, et al. Appl Microbiol Biotechnol, 2000 May. PMID 10855721
    2. Crystal structure of isoamyl acetate-hydrolyzing esterase from Saccharomyces cerevisiae reveals a novel active site architecture and the basis of substrate specificity. Ma J, et al. Proteins, 2011 Feb. PMID 21069734
    3. CRISPR-Cas genome engineering of esterase activity in Saccharomyces cerevisiae steers aroma formation. Dank A, et al. BMC Res Notes, 2018 Sep 27. PMID 30261908, Free PMC Article
    4. Regulation of Saccharomyces cerevisiae genetic engineering on the production of acetate esters and higher alcohols during Chinese Baijiu fermentation. Li W, et al. J Ind Microbiol Biotechnol, 2017 Jun. PMID 28176138
    5. Differential Analysis of Proteins Involved in Ester Metabolism in two Saccharomyces cerevisiae Strains during the Second Fermentation in Sparkling Wine Elaboration. González-Jiménez MDC, et al. Microorganisms, 2020 Mar 13. PMID 32183073, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of isoamyl acetate-hydrolyzing esterase from Saccharomyces cerevisiae
      Title: Crystal structure of isoamyl acetate-hydrolyzing esterase from Saccharomyces cerevisiae reveals a novel active site architecture and the basis of substrate specificity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    isoamyl acetate-hydrolyzing esterase
    NP_014769.3
    • Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      559961..560677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183545.3 → NP_014769.3  TPA: isoamyl acetate-hydrolyzing esterase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014769.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2I4, P41734, Q92313
      UniProtKB/TrEMBL
      A6ZNX3, B3LJG8, C7GML3, C8ZI88, G2WN01, N1NYG0
      Conserved Domains (1) summary
      cd01838
      Location:5 → 207
      Isoamyl_acetate_hydrolase_like; Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41734.1

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