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    aceA isocitrate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948517, updated on 17-Dec-2024

    Summary

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    Official Symbol
    aceA
    Official Full Name
    isocitrate lyase
    Primary source
    ECOCYC:EG10022
    Locus tag
    b4015
    See related
    ASAP:ABE-0013128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4007; icl
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    Genomic context

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    Sequence:
    NC_000913.3 (4217109..4218413)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene homoserine O-succinyltransferase Neighboring gene malate synthase A Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase kinase/phosphatase Neighboring gene regulator of acetyl CoA synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Site-directed mutagenesis of cysteine-195 in isocitrate lyase from Escherichia coli ML308. Robertson AG, et al. Biochem J, 1995 Jan 1. PMID 7826335, Free PMC Article
    2. Use of chemical modification in the crystallization of isocitrate lyase from Escherichia coli. Abeysinghe SI, et al. J Mol Biol, 1991 Jul 5. PMID 2067012
    3. The importance of four histidine residues in isocitrate lyase from Escherichia coli. Diehl P, et al. J Bacteriol, 1994 Feb. PMID 8300547, Free PMC Article
    4. Sub-optimal phenotypes of double-knockout mutants of Escherichia coli depend on the order of gene deletions. Gawand P, et al. Integr Biol (Camb), 2015 Aug. PMID 26079398, Free PMC Article
    5. The interaction of 3-phosphoglycerate and other substrate analogs with the glyoxylate- and succinate-binding sites of isocitrate lyase. Ko YH, et al. Arch Biochem Biophys, 1989 Oct. PMID 2673042

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Acid- and base-induced proteins during aerobic and anaerobic growth of Escherichia coli revealed by two-dimensional gel electrophoresis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cation binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isocitrate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isocitrate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glyoxylate cycle EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within glyoxylate cycle IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    isocitrate lyase
    NP_418439.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4217109..4218413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418439.1 isocitrate lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418439.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CF72, A0A1X3HXQ7, A0A1X3J9F2, A0A829LCB4, A0AA36L2L3, A0AAN3M8L3, F4T6P7
      Conserved Domains (1) summary
      PRK15063
      Location:1 → 434
      PRK15063; isocitrate lyase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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