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    dhaR DNA-binding transcriptional dual regulator DhaR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945743, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dhaR
    Official Full Name
    DNA-binding transcriptional dual regulator DhaR
    Primary source
    ECOCYC:G6628
    Locus tag
    b1201
    See related
    ASAP:ABE-0004033
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1189; ycgU
    Summary
    DhaR is an auto-repressor of dhaR transcription. [More information is available at EcoGene: EG13902]. "Dihydroxyacetone Regulator," DhaR, is negatively autoregulated and coordinately activates transcription of the divergent Dha operon (dhaKLM), which encodes three subunits of the dihydroxyacetone (Dha) kinase . [More information is available at EcoCyc: G6628].
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    Genomic context

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    Sequence:
    NC_000913.3 (1251066..1252985)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dihydroxyacetone kinase subunit L Neighboring gene dihydroxyacetone kinase subunit K Neighboring gene putative autotransporter adhesin YcgV Neighboring gene redox-responsive ATPase YchF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coiled-coil helix rotation selects repressing or activating state of transcriptional regulator DhaR. Shi R, et al. Structure, 2014 Mar 4. PMID 24440518
    2. Small substrate, big surprise: fold, function and phylogeny of dihydroxyacetone kinases. Erni B, et al. Cell Mol Life Sci, 2006 Apr. PMID 16505971, Free PMC Article
    3. Functional genomic studies of dihydroxyacetone utilization in Escherichia coli. Paulsen IT, et al. Microbiology (Reading), 2000 Oct. PMID 11021910
    4. An inducible phosphoenolpyruvate: dihydroxyacetone phosphotransferase system in Escherichia coli. Jin RZ, et al. J Gen Microbiol, 1984 Jan. PMID 6368745
    5. Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR. Bächler C, et al. EMBO J, 2005 Jan 26. PMID 15616579, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator DhaR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1251066..1252985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415719.2 DNA-binding transcriptional dual regulator DhaR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415719.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JJL9, A0A6D1FRL8
      Conserved Domains (1) summary
      PRK11388
      Location:1 → 638
      PRK11388; DNA-binding transcriptional regulator DhaR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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