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    cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946517, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cobT
    Official Full Name
    nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
    Primary source
    ECOCYC:EG12151
    Locus tag
    b1991
    See related
    ASAP:ABE-0006611
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1986
    Summary
    Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . cobT encodes a predicted dimethylbenzimidazole phosphoribosyltransferase. [More information is available at EcoCyc: EG12151].
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    Genomic context

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    Sequence:
    NC_000913.3 (2063388..2064467, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene L,D-transpeptidase LdtA Neighboring gene cobalamin 5'-phosphate synthase Neighboring gene cobinamide-P guanylyltransferase/cobinamide kinase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article
    2. The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. Lawrence JG, et al. J Bacteriol, 1995 Nov. PMID 7592411, Free PMC Article
    3. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040
    4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
    5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cobalamin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cobalamin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
    NP_416495.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2063388..2064467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416495.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416495.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L9HVU9
      Conserved Domains (1) summary
      PRK00105
      Location:14 → 348
      cobT; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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