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    cyaY frataxin CyaY [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947754, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cyaY
    Official Full Name
    frataxin CyaY
    Primary source
    ECOCYC:EG11653
    Locus tag
    b3807
    See related
    ASAP:ABE-0012435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3801
    Summary
    Frataxin-related. [More information is available at EcoGene: EG11653]. CyaY is a protein with similarity to human frataxin, mutations in which are responsible for Friedreich's ataxia. [More information is available at EcoCyc: EG11653].
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    Genomic context

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    Sequence:
    NC_000913.3 (3993739..3994059, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uroporphyrinogen-III synthase Neighboring gene hydroxymethylbilane synthase Neighboring gene adenylate cyclase Neighboring gene protein YzcX Neighboring gene putative lipoprotein YifL Neighboring gene diaminopimelate epimerase Neighboring gene DUF484 domain-containing protein YigA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly. Huynen MA, et al. Hum Mol Genet, 2001 Oct 1. PMID 11689493
    2. NMR assignment of the 1H, 15N and 13C resonances of the E. coli frataxin orthologue, CyaY. Nair M, et al. J Biomol NMR, 2003 Dec. PMID 14512742
    3. Iron binding and oxidation kinetics in frataxin CyaY of Escherichia coli. Bou-Abdallah F, et al. J Mol Biol, 2004 Aug 6. PMID 15276847
    4. Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites. Nair M, et al. Structure, 2004 Nov. PMID 15530368
    5. Crystallization and preliminary X-ray crystallographic analysis of Escherichia coli CyaY, a structural homologue of human frataxin. Lee MG, et al. Acta Crystallogr D Biol Crystallogr, 2000 Jul. PMID 10930845

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We have demonstrated that a single mutation in the scaffold protein IscU rendered E. coli viability strictly dependent upon a functional CyaY.
      Title: Turning Escherichia coli into a Frataxin-Dependent Organism.
    2. CyaY potentiates E. coli fitness, belongs to the ISC pathway catalyzing the maturation of Fe-S cluster-containing proteins and requires iron-rich conditions for its contribution to be significant; a genetic interaction was discovered between cyaY and iscX
      Title: The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli.
    3. CyaY participates in iron-sulfur (Fe-S) cluster assembly as an iron-dependent inhibitor of cluster formation, through binding to the desulfurase IscS.
      Title: Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS.
    4. CyaY is located in the cytoplasm
      Title: Effects of the deletion of the Escherichia coli frataxin homologue CyaY on the respiratory NADH:ubiquinone oxidoreductase.
    5. IscA recruits intracellular iron for the iron-sulfur cluster assembly under normal physiological conditions, whereas CyaY may serve as an iron chaperon to sequester redox active free iron under oxidative stress conditions
      Title: Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.
    6. Escherichia coli CYaY is an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU
      Title: Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    frataxin CyaY

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3993739..3994059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418251.1 frataxin CyaY [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418251.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AR44
      Conserved Domains (1) summary
      PRK00446
      Location:1 → 106
      cyaY; frataxin-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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