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    dld quinone-dependent D-lactate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946653, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dld
    Official Full Name
    quinone-dependent D-lactate dehydrogenase
    Primary source
    ECOCYC:EG10231
    Locus tag
    b2133
    See related
    ASAP:ABE-0007048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2126; ldh
    Summary
    There are three lactate dehydrogenase enzymes in Escherichia coli which interconvert pyruvate and lactate. [More information is available at EcoCyc: EG10231].
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    Genomic context

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    Sequence:
    NC_000913.3 (2222185..2223900)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycine betaine ABC transporter periplasmic binding protein OsmF Neighboring gene beta-D-glucoside glucohydrolase, periplasmic Neighboring gene peptidoglycan DD-endopeptidase PbpG Neighboring gene putative inner membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and properties of D-lactate dehydrogenase from Escherichia coli ML 308-225. Kaczorowski G, et al. Methods Enzymol, 1978. PMID 362128
    2. Biochemical and biophysical studies on the interaction of a membrane-bound enzyme, D-lactate dehydrogenase from Escherichia coli, with phospholipids. Fung LW, et al. Biochemistry, 1979 Jan 23. PMID 369600
    3. D- and L-lactic acid oxidases of Escherichia coli. HAUGAARD N. Biochim Biophys Acta, 1959 Jan. PMID 13628604
    4. Inactive and temperature-sensitive folding mutants generated by tryptophan substitutions in the membrane-bound d-lactate dehydrogenase of Escherichia coli. Truong HT, et al. Biochemistry, 1991 Nov 5. PMID 1931992
    5. Overproduction and nucleotide sequence of the respiratory D-lactate dehydrogenase of Escherichia coli. Rule GS, et al. J Bacteriol, 1985 Mar. PMID 3882663, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Overproduction and nucleotide sequence of the respiratory D-lactate dehydrogenase of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-lactate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aerobic respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within anaerobic respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lactate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within respiratory electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    quinone-dependent D-lactate dehydrogenase
    NP_416637.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2222185..2223900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416637.1 quinone-dependent D-lactate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416637.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QX47
      Conserved Domains (1) summary
      PRK11183
      Location:8 → 569
      PRK11183; D-lactate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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