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    gabD succinate-semialdehyde dehydrogenase (NADP(+)) GabD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948060, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gabD
    Official Full Name
    succinate-semialdehyde dehydrogenase (NADP(+)) GabD
    Primary source
    ECOCYC:EG11329
    Locus tag
    b2661
    See related
    ASAP:ABE-0008758
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2655
    Summary
    Escherichia coli K-12 encodes two succinate semialdehyde dehydrogenases which differ in their ability to utilize NAD+ and NADP+. [More information is available at EcoCyc: EG11329].
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    Genomic context

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    Sequence:
    NC_000913.3 (2791273..2792721)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutarate dioxygenase GlaH Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene 4-aminobutyrate aminotransferase GabT Neighboring gene 4-aminobutanoate:H(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions. Langendorf CG, et al. PLoS One, 2010 Feb 18. PMID 20174634, Free PMC Article
    2. Crystal structure of non-redox regulated SSADH from Escherichia coli. Ahn JW, et al. Biochem Biophys Res Commun, 2010 Jan 29. PMID 20060383
    3. Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Jaeger M, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18474219
    4. Separation and characterization of NAD- and NADP-specific succinate-semialdehyde dehydrogenase from Escherichia coli K-12 3300. Cozzani I, et al. Biochim Biophys Acta, 1980 Jun 13. PMID 7004491
    5. Two succinic semialdehyde dehydrogenases are induced when Escherichia coli K-12 Is grown on gamma-aminobutyrate. Donnelly MI, et al. J Bacteriol, 1981 Mar. PMID 7009588, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that a deletion of three amino acids in gabD gene (SSADH) permits this enzyme to use NADP+.
      Title: The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.
    2. the crystal structure of EcSSADH, revealing that the catalytic loop of EcSSADH, unlike that of human SSADH, was presented.
      Title: Crystal structure of non-redox regulated SSADH from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutarate-semialdehyde dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutarate-semialdehyde dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate-semialdehyde dehydrogenase (NADP(+)) GabD
    NP_417147.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2791273..2792721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417147.1 succinate-semialdehyde dehydrogenase (NADP(+)) GabD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417147.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GJV3
      Conserved Domains (1) summary
      PRK11241
      Location:1 → 482
      gabD; NADP-dependent succinate-semialdehyde dehydrogenase I
    Nucleotide Protein
    Heading Accession and Version

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