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    ompC outer membrane porin C [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946716, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ompC
    Official Full Name
    outer membrane porin C
    Primary source
    ECOCYC:EG10670
    Locus tag
    b2215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2207; meoA; par
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10670]. OmpC is a member of the GMP family. [More information is available at EcoCyc: EG10670].
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    Genomic context

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    Sequence:
    NC_000913.3 (2311646..2312749, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA oxidative demethylase Neighboring gene DNA-binding transcriptional dual regulator/DNA repair protein Ada Neighboring gene FAD:protein FMN transferase Neighboring gene ncRNA Neighboring gene RcsD phosphotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of side tail fibers during the infection cycle of phage lambda. Guan J, et al. Virology, 2019 Jan 15. PMID 30463036, Free PMC Article
    2. A genetic approach for analysing surface-exposed regions of the OmpC protein of Escherichia coli K-12. Vakharia H, et al. Mol Microbiol, 1996 Feb. PMID 8820656
    3. Crystal structure of osmoporin OmpC from E. coli at 2.0 A. Baslé A, et al. J Mol Biol, 2006 Oct 6. PMID 16949612
    4. Functional assay of Salmonella typhi OmpC using reconstituted large unilamellar vesicles: a general method for characterization of outer membrane proteins. Sundara Baalaji N, et al. Biochimie, 2006 Oct. PMID 16765505
    5. Effects of pore mutations and permeant ion concentration on the spontaneous gating activity of OmpC porin. Liu N, et al. Protein Eng, 2000 Jul. PMID 10906344

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
      Title: LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
    2. findings reveal an unknown OmpC-dependent mechanism of ethanol tolerance in a manner of EnvZ/OmpR regulation.
      Title: Identification of ethanol tolerant outer membrane proteome reveals OmpC-dependent mechanism in a manner of EnvZ/OmpR regulation in Escherichia coli.
    3. Klebsiella pneumoniae OmpK35 and OmpK36 produced larger more permeable channels than their Escherichia coli homologs OmpF and OmpC.
      Title: Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs OmpF and OmpC.
    4. established that OmpC is an additional component of the Mla system; the OmpC-MlaA complex may function to remove phospholipids directly from the outer leaflet to maintain outer membrane lipid asymmetry;work reveals a novel function for the general diffusion channel OmpC in lipid transport
      Title: Osmoporin OmpC forms a complex with MlaA to maintain outer membrane lipid asymmetry in Escherichia coli.
    5. Studied the rate of entry (association) and exit (dissociation) of six antibiotics to/from reconstituted E. coli porin OmpC. WaterMap was used to estimate the total water transfer energies resulting from transient occupation by each antibiotic.
      Title: The translocation kinetics of antibiotics through porin OmpC: insights from structure-based solvation mapping using WaterMap.
    6. N-terminus verified by Edman degradation on mature peptide
      Title: Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.
    7. OmpF or OmpC can function in the translocon complex of the colicin E2 R-domain and its BtuB receptor
      Title: Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon.
    8. for the classical porins OmpF and OmpC, our results show that the Cpx envelope stress response system plays a role in regulating their expression
      Title: The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
    9. X ray structure of OmpC complexed with lactoferrin
      Title: High-resolution diffraction from crystals of a membrane-protein complex: bacterial outer membrane protein OmpC complexed with the antibacterial eukaryotic protein lactoferrin.
    10. OmpR allows distinct stepwise regulation of ompF and ompC transcription, which minimizes their overlapping expression upon changes in the medium osmolarity to achieve the reciprocal expression of ompF and ompC
      Title: Transcription regulation of ompF and ompC by a single transcription factor, OmpR.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables porin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables virus receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within intermembrane phospholipid transfer EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated virion attachment to host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pore complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    outer membrane porin C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2311646..2312749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416719.1 outer membrane porin C [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416719.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7IK29, C6K7N0, C6K7N1, C6K7N3, K7DXB2
      Conserved Domains (1) summary
      PRK10554
      Location:14 → 367
      PRK10554; outer membrane porin protein C; Provisional
    Nucleotide Protein
    Heading Accession and Version

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