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    rfbA glucose-1-phosphate thymidylyltransferase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945154, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rfbA
    Official Full Name
    glucose-1-phosphate thymidylyltransferase 1
    Primary source
    ECOCYC:EG11978
    Locus tag
    b2039
    See related
    ASAP:ABE-0006762
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2033; rmlA; som
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    Genomic context

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    Sequence:
    NC_000913.3 (2110138..2111019, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative O-antigen polymerase Neighboring gene UDP-galactopyranose mutase Neighboring gene polyisoprenol-linked O16-antigen repeat unit flippase Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene dTDP-4-dehydrorhamnose reductase Neighboring gene dTDP-glucose 4,6-dehydratase 1 Neighboring gene UTP:glucose-1-phosphate uridylyltransferase, low activity

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [RmlA gene deletion affects biofilm formation by avian pathogenic Escherichia coli]. Han Y, et al. Wei Sheng Wu Xue Bao, 2013 Oct 4. PMID 24409761
    2. Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase. Zuccotti S, et al. J Mol Biol, 2001 Nov 2. PMID 11697907
    3. Era and RbfA have overlapping function in ribosome biogenesis in Escherichia coli. Inoue K, et al. J Mol Microbiol Biotechnol, 2006. PMID 16825789
    4. Molecular typing of Escherichia coli strains isolated from food in Casablanca (Morocco). Badri S, et al. Cell Mol Biol (Noisy-le-grand), 2009 Jun 15. PMID 19656466
    5. Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1. Klena JD, et al. Mol Microbiol, 1993 Jul. PMID 7692219

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The rmlA deletion mutant did not affect the growth and motility but enhanced the biofilm formation.
      Title: [RmlA gene deletion affects biofilm formation by avian pathogenic Escherichia coli].
    2. Results showed a reproducible and clear cut classification with molecular polymorphism of rfb gene cluster and flagella gene fliC.
      Title: Molecular typing of Escherichia coli strains isolated from food in Casablanca (Morocco).
    3. Era and RbfA have an overlapping function that is essential for ribosome biogenesis.
      Title: Era and RbfA have overlapping function in ribosome biogenesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glucose-1-phosphate thymidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-1-phosphate thymidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in O antigen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTDP-rhamnose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose-1-phosphate thymidylyltransferase 1
    NP_416543.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2110138..2111019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416543.1 glucose-1-phosphate thymidylyltransferase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416543.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9AK78
      Conserved Domains (1) summary
      TIGR01207
      Location:5 → 290
      rmlA; glucose-1-phosphate thymidylyltransferase, short form
    Nucleotide Protein
    Heading Accession and Version

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