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    treA periplasmic trehalase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945757, updated on 3-Dec-2024

    Summary

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    Official Symbol
    treA
    Official Full Name
    periplasmic trehalase
    Primary source
    ECOCYC:EG11017
    Locus tag
    b1197
    See related
    ASAP:ABE-0004021
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1185; osmA; tre
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    Genomic context

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    Sequence:
    NC_000913.3 (1245679..1247376, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF04226 family protein YmgE Neighboring gene uncharacterized protein YcgY Neighboring gene dihydroxyacetone kinase subunit M Neighboring gene dihydroxyacetone kinase subunit L

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families. Cardona F, et al. Chemistry, 2009. PMID 19123216
    2. Osmotic induction of the periplasmic trehalase in Escherichia coli K12: characterization of the treA gene promoter. Repoila F, et al. Mol Microbiol, 1991 Mar. PMID 1710760
    3. Synthesis, accumulation, and excretion of trehalose in osmotically stressed Escherichia coli K-12 strains: influence of amber suppressors and function of the periplasmic trehalase. Styrvold OB, et al. J Bacteriol, 1991 Feb. PMID 1825082, Free PMC Article
    4. Periplasmic trehalase from Escherichia coli--characterization and immobilization on spherisorb. Tourinho-dos-Santos CF, et al. Braz J Med Biol Res, 1994 Mar. PMID 8081287
    5. The Periplasmic Trehalase Affects Type 1 Fimbria Production and Virulence of Extraintestinal Pathogenic Escherichia coli Strain MT78. Pavanelo DB, et al. Infect Immun, 2018 Aug. PMID 29844238, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results show that the treA gene is needed for optimal production of type 1 fimbriae in extraintestinal pathogenic Escherichia coli strain MT78 and that loss of treA significantly reduces its cell invasion capacity and colonization of the bladder in a murine model of urinary tract infection.
      Title: The Periplasmic Trehalase Affects Type 1 Fimbria Production and Virulence of Extraintestinal Pathogenic Escherichia coli Strain MT78.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Analysis and DNA sequence of the osmoregulated treA gene encoding the periplasmic trehalase of Escherichia coli K12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha,alpha-trehalase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in trehalose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in trehalose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within trehalose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trehalose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    periplasmic trehalase
    NP_415715.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1245679..1247376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415715.1 periplasmic trehalase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415715.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376K0I5, A0A895NUX1
      Conserved Domains (1) summary
      PRK13271
      Location:1 → 565
      treA; alpha,alpha-trehalase TreA
    Nucleotide Protein
    Heading Accession and Version

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