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    entH proofreading thioesterase in enterobactin biosynthesis [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945215, updated on 3-Dec-2024

    Summary

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    Official Symbol
    entH
    Official Full Name
    proofreading thioesterase in enterobactin biosynthesis
    Primary source
    ECOCYC:EG11105
    Locus tag
    b0597
    See related
    ASAP:ABE-0002057
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0590; ybdB
    Summary
    EntH is a member of the hotdog superfamily. [More information is available at EcoGene: EG11105]. EntH is a thioesterase that is involved in the biosynthesis of enterobactin . [More information is available at EcoCyc: EG11105].
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    Genomic context

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    Sequence:
    NC_000913.3 (629300..629713)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2,3-dihydroxybenzoate-AMP ligase Neighboring gene enterobactin synthase component B Neighboring gene 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase Neighboring gene pyruvate transporter CstA Neighboring gene PF04328 family protein YbdD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preferential hydrolysis of aberrant intermediates by the type II thioesterase in Escherichia coli nonribosomal enterobactin synthesis: substrate specificities and mutagenic studies on the active-site residues. Guo ZF, et al. Biochemistry, 2009 Mar 3. PMID 19193103
    2. In vitro kinetic analysis of substrate specificity in enterobactin biosynthetic lower pathway enzymes provides insight into the biochemical function of the hot dog-fold thioesterase EntH. Chen D, et al. Biochemistry, 2009 Jan 27. PMID 19119850, Free PMC Article
    3. Nucleotide sequence and transcriptional organization of the Escherichia coli enterobactin biosynthesis cistrons entB and entA. Nahlik MS, et al. J Bacteriol, 1989 Feb. PMID 2521621, Free PMC Article
    4. Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. Liu J, et al. J Bacteriol, 1989 Feb. PMID 2521622, Free PMC Article
    5. Nucleotide sequence of Escherichia coli isochorismate synthetase gene entC and evolutionary relationship of isochorismate synthetase and other chorismate-utilizing enzymes. Ozenberger BA, et al. J Bacteriol, 1989 Feb. PMID 2536681, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show YbdB thioesterase activity could be required for cleaving wrongly charged molecules on the carrier protein EntB.
      Title: The hotdog thioesterase EntH (YbdB) plays a role in vivo in optimal enterobactin biosynthesis by interacting with the ArCP domain of EntB.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thiolester hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiolester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in enterobactin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enterobactin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proofreading thioesterase in enterobactin biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      629300..629713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415129.1 proofreading thioesterase in enterobactin biosynthesis [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415129.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GLY0, A0A3L9GKK5
      Conserved Domains (1) summary
      PRK10254
      Location:1 → 137
      PRK10254; proofreading thioesterase EntH
    Nucleotide Protein
    Heading Accession and Version

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