TRS20 TRAPP subunit TRS20 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRS20
Official Full Name: TRAPP subunit TRS20
Primary source: SGD:S000000458
Locus tag: YBR254C
See related: AllianceGenome:SGD:S000000458; FungiDB:YBR254C; VEuPathDB:YBR254C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein-containing complex assembly. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Used to study X-linked spondyloepiphyseal dysplasia tarda and spondyloepiphyseal dysplasia congenita. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to human TRAPPC2 (trafficking protein particle complex subunit 2) and TRAPPC2B (trafficking protein particle complex subunit 2B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TRS20 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (723736..724263, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trs20 plays a role as an adaptor in the assembly of TRAPP II and TRAPP III complexes and is required for autophagy.
Title: Trs20 is required for TRAPP III complex assembly at the PAS and its function in autophagy.
Mutation in Trs20 led to defects in endocytic recycling and a block in sporulation/meiosis.
Title: Mutational analysis of the yeast TRAPP subunit Trs20p identifies roles in endocytic recycling and sporulation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of TRAPP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAPPI protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPPII protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPPIII protein complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TRAPP subunit TRS20

NP_009813.1

Core component of transport protein particle (TRAPP) complexes I-III; TRAPPs are multimeric guanine nucleotide-exchange factors for GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation leads to defects in endocytic recycling, block in sporulation/meiosis; mutations in human homolog TRAPPC2 cause spondyloepiphyseal dysplasia tarda, TRAPPC2 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

723736..724263 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178602.1 → NP_009813.1 TPA: TRAPP subunit TRS20 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009813.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQQ0, P38334

UniProtKB/TrEMBL

A6ZLJ3, B3LMQ8, B5VEK3, C7GMX7, D3UF01, N1P758

Conserved Domains (1) summary

COG5603
Location:1 → 173

TRS20; Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion]