U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VTC2 vacuolar transporter chaperone [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850544, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VTC2
    Official Full Name
    vacuolar transporter chaperone
    Primary source
    SGD:S000001890
    Locus tag
    YFL004W
    See related
    AllianceGenome:SGD:S000001890; FungiDB:YFL004W; VEuPathDB:YFL004W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PHM1
    Summary
    Enables calmodulin binding activity. Involved in several processes, including microautophagy; polyphosphate metabolic process; and vacuole fusion, non-autophagic. Located in endoplasmic reticulum and fungal-type vacuole membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VTC2 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (131810..134296)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Rab family GTPase SEC4 Neighboring gene ncRNA Neighboring gene MutS family protein MSH4 Neighboring gene tRNA-Asn

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. One-Step Biosynthesis of Vitamin C in Saccharomyces cerevisiae. Zhou M, et al. Front Microbiol, 2021. PMID 33717042, Free PMC Article
    2. The macro domain as fusion tag for carrier-driven crystallization. Wild R, et al. Protein Sci, 2017 Feb. PMID 27774698, Free PMC Article
    3. Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction. Pipercevic J, et al. Nat Commun, 2023 May 8. PMID 37156835, Free PMC Article
    4. Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Hothorn M, et al. Science, 2009 Apr 24. PMID 19390046
    5. Role of the Vtc proteins in V-ATPase stability and membrane trafficking. Müller O, et al. J Cell Sci, 2003 Mar 15. PMID 12584253

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyphosphate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polyphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar transporter chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    vacuolar transporter chaperone
    NP_116651.1
    • Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC2 has a paralog, VTC3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      131810..134296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179962.1 → NP_116651.1  TPA: vacuolar transporter chaperone [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116651.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTM5, P43585
      UniProtKB/TrEMBL
      A7A234, G2WDD6
      Conserved Domains (2) summary
      COG5036
      Location:1 → 555
      COG5036; SPX domain-containing protein involved in vacuolar polyphosphate accumulation [Inorganic ion transport and metabolism, Intracellular trafficking, secretion, and vesicular transport]
      COG5264
      Location:662 → 791
      VTC1; Vacuolar transporter chaperone [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43585.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools