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    Fmo1 flavin containing monooxygenase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14261, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fmo1provided by MGI
    Official Full Name
    flavin containing monooxygenase 1provided by MGI
    Primary source
    MGI:MGI:1310002
    See related
    Ensembl:ENSMUSG00000040181 AllianceGenome:MGI:1310002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables hypotaurine monooxygenase activity. Involved in taurine biosynthetic process. Acts upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in brain; cortical renal tubule; late tubule; and testis. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 131.1), placenta adult (RPKM 107.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fmo1 in Genome Data Viewer
    Location:
    1 H2.1; 1 70.34 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162657130..162694170, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162829561..162866610, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2C Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:164658175-164658482 Neighboring gene STARR-positive B cell enhancer ABC_E1234 Neighboring gene STARR-seq mESC enhancer starr_02843 Neighboring gene STARR-seq mESC enhancer starr_02844 Neighboring gene flavin containing monooxygenase 4 Neighboring gene STARR-seq mESC enhancer starr_02845 Neighboring gene VISTA enhancer mm713 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene predicted gene, 32197 Neighboring gene flavin containing monooxygenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice. Li B, et al. Neurosci Lett, 2021 Nov 1. PMID 34500002
    2. Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). Itoh K, et al. J Toxicol Sci, 1997 Feb. PMID 9076656
    3. Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos). Janmohamed A, et al. Biochem Pharmacol, 2004 Jul 1. PMID 15183119
    4. Determination of cellular localization of expression of flavin-containing monooxygenase genes in mouse tissues by in situ hybridization. Janmohamed A, et al. Methods Mol Biol, 2006. PMID 16719401
    5. Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse. Shephard EA, et al. Biochem J, 2007 Sep 15. PMID 17547558, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.
      Title: Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.
    2. Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT).
      Title: The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
    3. Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioral responses to imipramine.
      Title: Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.
    4. The functional activity of Fmo1 was determined.
      Title: Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5.
    5. Fmo1, 2, 3, 4 and 5 exhibit distinct cell-, tissue-, sex- and developmental stage-specific patterns of expression.
      Title: Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hypotaurine monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables trimethylamine monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trimethylamine monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within energy homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fatty acid oxidation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in organic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in taurine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in taurine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toxin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within xenobiotic metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    flavin-containing monooxygenase 1
    Names
    dimethylaniline monooxygenase [N-oxide-forming] 1
    dimethylaniline oxidase 1
    hepatic flavin-containing monooxygenase 1
    trimethylamine monooxygenase
    NP_001317220.1
    NP_001317247.1
    NP_001407099.1
    NP_001407100.1
    NP_001407101.1
    NP_001407102.1
    NP_001407103.1
    NP_001407104.1
    NP_034361.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330291.2 → NP_001317220.1  flavin-containing monooxygenase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      Consensus CDS
      CCDS15424.1
      UniProtKB/Swiss-Prot
      P50285
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like

    2. NM_001330318.2 → NP_001317247.1  flavin-containing monooxygenase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      Consensus CDS
      CCDS87907.1
      UniProtKB/TrEMBL
      Q8C9C1
      Related
      ENSMUSP00000107143.2, ENSMUST00000111518.3
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 161
      FMO-like; Flavin-binding monooxygenase-like

    3. NM_001420170.1 → NP_001407099.1  flavin-containing monooxygenase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      UniProtKB/Swiss-Prot
      P50285

    4. NM_001420171.1 → NP_001407100.1  flavin-containing monooxygenase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      UniProtKB/Swiss-Prot
      P50285

    5. NM_001420172.1 → NP_001407101.1  flavin-containing monooxygenase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      Related
      ENSMUSP00000118534.3, ENSMUST00000131058.8

    6. NM_001420173.1 → NP_001407102.1  flavin-containing monooxygenase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      Related
      ENSMUSP00000141210.2, ENSMUST00000193078.6

    7. NM_001420174.1 → NP_001407103.1  flavin-containing monooxygenase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      UniProtKB/TrEMBL
      Q8C9C1

    8. NM_001420175.1 → NP_001407104.1  flavin-containing monooxygenase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      UniProtKB/TrEMBL
      Q8C9C1

    9. NM_010231.4 → NP_034361.1  flavin-containing monooxygenase 1 isoform 1

      See identical proteins and their annotated locations for NP_034361.1

      Status: VALIDATED

      Source sequence(s)
      AC117767, AC118643
      Consensus CDS
      CCDS15424.1
      UniProtKB/Swiss-Prot
      P50285
      Related
      ENSMUSP00000037259.8, ENSMUST00000046049.14
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      162657130..162694170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50285.1 GenPept UniProtKB/Swiss-Prot:P50285

    Gene LinkOut

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