Castor2 cytosolic arginine sensor for mTORC1 subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Castor2provided by MGI
Official Full Name: cytosolic arginine sensor for mTORC1 subunit 2provided by MGI
Primary source: MGI:MGI:1933384
See related: Ensembl:ENSMUSG00000015944 AllianceGenome:MGI:1933384
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gats; Gatsl1; Gatsl2; 7530428J21Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Orthologous to several human genes including CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 8.6), frontal lobe adult (RPKM 7.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 74.39 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (134128587..134170621)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (134099748..134141782)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

G48137 (e-PCR)
- UniSTS:95246

G48138 (e-PCR)
- UniSTS:95247

AW742413 (e-PCR)
- UniSTS:207888

G48139 (e-PCR)
- UniSTS:95248

G48140 (e-PCR)
- UniSTS:95249

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to L-arginine	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of GATOR2 complex	ISO Inferred from Sequence Orthology more info
part_of GATOR2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytosolic arginine sensor for mTORC1 subunit 2

Names: GATS protein-like 2; GATS-like protein 1; GATS-like protein 2; opposite strand transcription unit to Stag3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.