Orco Odorant receptor co-receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Orcoprovided by FlyBase
Official Full Name: Odorant receptor co-receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0037324
Locus tag: Dmel_CG10609
See related: AllianceGenome:FB:FBgn0037324
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 83A.2; 83b; A45; CG10609; DmelOrco; Dmel\CG10609; DmOrco; DmORCO; DOR45; DOR83b; OR49; or83b; Or83b; OR83b; OR83B; orco; OrCo; ORCO; vainsA
Summary: Enables several functions, including calmodulin binding activity; coreceptor activity; and protein homodimerization activity. Contributes to ionotropic olfactory receptor activity. Involved in several processes, including behavioral response to ethanol; detection of chemical stimulus involved in sensory perception of smell; and olfactory behavior. Located in cilium; dendrite; and plasma membrane. Part of cation channel complex. Is expressed in several structures, including adult brain; adult head sensillum; antennal lobe; olfactory receptor neurons; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83A2-83A2; 3-47.5 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5407183..5412406, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1232905..1238128, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity.
Title: Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity.
Calmodulin regulates the olfactory performance in Drosophila melanogaster.
Title: Calmodulin regulates the olfactory performance in Drosophila melanogaster.
Kinesin-2 transports Orco into the olfactory cilium of Drosophila melanogaster at specific developmental stages.
Title: Kinesin-2 transports Orco into the olfactory cilium of Drosophila melanogaster at specific developmental stages.
Data suggest that Orco interactome, which includes physiologically meaningful candidates, would guide further research on the molecular mechanisms of the insect odorant receptor family.
Title: Mass Spectrometry-Based Screening Platform Reveals Orco Interactome in Drosophila melanogaster.
OrcoS289 mutant flies unable to regulate Orco function through phosphorylation at S289 are defective for odor-guided behavior.
Title: Odorant Receptor Sensitivity Modulation in Drosophila.
Both the defects are rescued by the somatic cyst cell-specific expression of the UAS-orco transgene. These results highlight a novel role of Orco in the somatic tissue during sperm release.
Title: A conditional Orco requirement in the somatic cyst cells for maintaining spermatids in a tight bundle in Drosophila testis.
we show that insect ORs(DmOR67a, DmOR85b and DmORCO) and their co-receptor can be expressed in an E. coli cell-free system
Title: Cell-free expression, purification, and ligand-binding analysis of Drosophila melanogaster olfactory receptors DmOR67a, DmOR85b and DmORCO.
intracellular loop 3 is important for Orco channel activation
Title: Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from Drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation.
Study investigated the importance of two conserved Asp residues, one in each of transmembrane domains 5 and 7, for channel function by mutagenesis and found that the Asp residue associated with Orco TM7 is linked to channel activation.
Title: A conserved aspartic acid is important for agonist (VUAA1) and odorant/tuning receptor-dependent activation of the insect odorant co-receptor (Orco).
odorant receptors thus form ligand-gated channels as well as complexes of odorant-sensing units and cyclic-nucleotide-activated non-selective cation channels
Title: Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calmodulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	ISM Inferred from Sequence Model more info	PubMed
enables coreceptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables intracellularly gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to ionotropic olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ionotropic olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to ionotropic olfactory receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables odorant binding	IEA Inferred from Electronic Annotation more info
enables odorant binding	IPI Inferred from Physical Interaction more info	PubMed
enables odorant binding	ISS Inferred from Sequence or Structural Similarity more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of smell	NAS Non-traceable Author Statement more info	PubMed
involved_in sensory perception of smell	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of cation channel complex	TAS Traceable Author Statement more info	PubMed
colocalizes_with cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendrite membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: odorant receptor co-receptor

Names: CG10609-PA; CG10609-PB; Or83b; Orco-PA; Orco-PB; odorant receptor 83b; odorant receptor coreceptor; olfactory co-receptor; olfactory coreceptor; olfactory receptor co-receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5407183..5412406 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001104217.2 → NP_001097687.1 odorant receptor co-receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097687.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JQT8, Q672R0, Q9VNB5

UniProtKB/TrEMBL

G2J620

Conserved Domains (1) summary

pfam02949
Location:70 → 472

7tm_6; 7tm Odorant receptor
NM_079511.5 → NP_524235.2 odorant receptor co-receptor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524235.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JQT8, Q672R0, Q9VNB5

UniProtKB/TrEMBL

G2J620

Related

FBpp0078438

Conserved Domains (1) summary

pfam02949
Location:70 → 472

7tm_6; 7tm Odorant receptor