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    Htr5a 5-hydroxytryptamine (serotonin) receptor 5A [ Mus musculus (house mouse) ]

    Gene ID: 15563, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Htr5aprovided by MGI
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 5Aprovided by MGI
    Primary source
    MGI:MGI:96283
    See related
    Ensembl:ENSMUSG00000039106 AllianceGenome:MGI:96283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Htr5
    Summary
    Predicted to enable Gi/o-coupled serotonin receptor activity and neurotransmitter receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in perikaryon. Predicted to be active in dendrite and postsynaptic specialization membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and liver and biliary system. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.1), frontal lobe adult (RPKM 2.0) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Htr5a in Genome Data Viewer
    Location:
    5 B1; 5 13.24 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28046836..28059403)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (27841716..27855086)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3565 Neighboring gene STARR-seq mESC enhancer starr_12707 Neighboring gene STARR-seq mESC enhancer starr_12709 Neighboring gene predicted gene, 20239 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene Neighboring gene SPATA31 subfamily H, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. Plassat JL, et al. EMBO J, 1992 Dec. PMID 1464308, Free PMC Article
    2. The native serotonin 5-HT(5A) receptor: electrophysiological characterization in rodent cortex and 5-HT(1A)-mediated compensatory plasticity in the knock-out mouse. Goodfellow NM, et al. J Neurosci, 2012 Apr 25. PMID 22539842, Free PMC Article
    3. Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Grailhe R, et al. Neuron, 1999 Mar. PMID 10197537
    4. Cortisol regulates immune and metabolic processes in murine adipocytes and macrophages through HTR2c and HTR5a serotonin receptors. Priyadarshini S, et al. Eur J Cell Biol, 2018 Sep. PMID 30097291
    5. Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Matthes H, et al. Mol Pharmacol, 1993 Mar. PMID 8450829

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cortisol up-regulated the expression and function of two serotonin (S) receptors, HTR2c and HTR5a.
      Title: Cortisol regulates immune and metabolic processes in murine adipocytes and macrophages through HTR2c and HTR5a serotonin receptors.
    2. This study demonistrated that loss of htr5A gene strongly upregulates 5-HT1A receptor-mediated currents in the prefrontal cortex.
      Title: The native serotonin 5-HT(5A) receptor: electrophysiological characterization in rodent cortex and 5-HT(1A)-mediated compensatory plasticity in the knock-out mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables Gi/o-coupled serotonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 5A
    Names
    5-HT-5
    5-HT-5A
    5-HT5A
    serotonin receptor 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420120.1 → NP_001407049.1  5-hydroxytryptamine receptor 5A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132397

    2. NM_008314.3 → NP_032340.2  5-hydroxytryptamine receptor 5A isoform 1

      See identical proteins and their annotated locations for NP_032340.2

      Status: VALIDATED

      Source sequence(s)
      AC132397
      Consensus CDS
      CCDS19141.1
      UniProtKB/Swiss-Prot
      P30966, Q3URB0
      Related
      ENSMUSP00000038884.6, ENSMUST00000036227.7
      Conserved Domains (1) summary
      pfam00001
      Location:57 → 338
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      28046836..28059403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30966.2 GenPept UniProtKB/Swiss-Prot:P30966

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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