U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pdcd4 Programmed cell death 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32337, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pdcd4provided by FlyBase
    Official Full Name
    Programmed cell death 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0030520
    Locus tag
    Dmel_CG10990
    See related
    AllianceGenome:FB:FBgn0030520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10990; Dmel\CG10990; pdcd4
    Summary
    Involved in germarium-derived female germ-line cyst formation and positive regulation of stem cell differentiation. Located in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and synaptic neuropil domain. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pdcd4 in Genome Data Viewer
    Location:
    12B4-12B10; 1-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13745577..13755406, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13639610..13649439, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Gamma-tubulin ring protein 91 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42861 Neighboring gene antisense RNA:CR43833 Neighboring gene uncharacterized protein Neighboring gene Rtc1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4. Fehler O, et al. Nucleic Acids Res, 2014. PMID 25190455, Free PMC Article
    2. The insulin receptor cellular IRES confers resistance to eIF4A inhibition. Olson CM, et al. Elife, 2013 Jul 16. PMID 23878722, Free PMC Article
    3. Quantitative genomics of locomotor behavior in Drosophila melanogaster. Jordan KW, et al. Genome Biol, 2007. PMID 17708775, Free PMC Article
    4. Drosophila sperm development and intercellular cytoplasm sharing through ring canals do not require an intact fusome. Kaufman RS, et al. Development, 2020 Nov 15. PMID 33033119, Free PMC Article
    5. Identification of novel candidate genes leading to sex differentiation in primordial germ cells of Drosophila. Ota R, et al. Gene Expr Patterns, 2023 Jun. PMID 37142099

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pdcd4 promotes the differentiation of germline stem cells daughter cells by relieving the eIF4A-mediated inhibition of Bam. [Pdcd4]
      Title: Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in germarium-derived female germ-line cyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    programmed cell death 4
    Names
    CG10990-PA
    CG10990-PB
    CG10990-PC
    CG10990-PD
    Pdcd4-PA
    Pdcd4-PB
    Pdcd4-PC
    Pdcd4-PD
    programmed cell death 4 ortholog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13745577..13755406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272604.1 → NP_001259533.1  programmed cell death 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY91
      Conserved Domains (2) summary
      smart00544
      Location:197 → 308
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02847
      Location:363 → 476
      MA3; MA3 domain

    2. NM_001103507.3 → NP_001096977.1  programmed cell death 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY91
      Conserved Domains (2) summary
      smart00544
      Location:197 → 308
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02847
      Location:363 → 476
      MA3; MA3 domain

    3. NM_001272603.1 → NP_001259532.1  programmed cell death 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY91
      Conserved Domains (2) summary
      smart00544
      Location:197 → 308
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02847
      Location:363 → 476
      MA3; MA3 domain

    4. NM_132690.4 → NP_572918.1  programmed cell death 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY91
      Related
      FBpp0073671
      Conserved Domains (2) summary
      smart00544
      Location:197 → 308
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02847
      Location:363 → 476
      MA3; MA3 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY91 Q9VY91

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools