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    Wbp2 WW domain binding protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wbp2provided by FlyBase
    Official Full Name
    WW domain binding protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036318
    Locus tag
    Dmel_CG11009
    See related
    AllianceGenome:FB:FBgn0036318
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11009; Dmel\CG11009; wbp2; WWBP
    Summary
    Predicted to enable chromatin DNA binding activity and transcription coactivator activity. Involved in positive regulation of imaginal disc growth and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in adult head; embryonic/larval salivary gland; eye disc; larval brain; and wing disc. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Orthologous to several human genes including WBP2 (WW domain binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wbp2 in Genome Data Viewer
    Location:
    69E6-69E6; 3-39 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12850165..12853169)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12843265..12846269)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene nebulosa Neighboring gene uncharacterized protein Neighboring gene Equilibrative nucleoside transporter 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. Zhang X, et al. Cell Death Differ, 2011 Aug. PMID 21311569, Free PMC Article
    2. Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded. Hu L, et al. Cell Discov, 2016. PMID 27462444, Free PMC Article
    3. Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes. Jiang SY, et al. Dev Biol, 2008 Feb 15. PMID 18201690
    4. WW domain interactions regulate the Hippo tumor suppressor pathway. Salah Z, et al. Cell Death Dis, 2011 Jun 16. PMID 21677687, Free PMC Article
    5. Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression. Ghavi-Helm Y, et al. Nat Genet, 2019 Aug. PMID 31308546, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results define an important role for Wbp2 as a downstream component of the Salvador-Warts-Hippo tissue growth-control pathway.
      Title: Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of imaginal disc growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WW domain binding protein 2
    Names
    CG11009-PB
    CG11009-PC
    CG11009-PD
    CG11009-PE
    CG11009-PF
    CG11009-PG
    Wbp2 ortholog
    Wbp2-PB
    Wbp2-PC
    Wbp2-PD
    Wbp2-PE
    Wbp2-PF
    Wbp2-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12850165..12853169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144472.3 → NP_001137944.1  WW domain binding protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SE8
      Conserved Domains (1) summary
      cd13214
      Location:27 → 129
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    2. NM_001144473.3 → NP_001137945.1  WW domain binding protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SE8
      Conserved Domains (1) summary
      cd13214
      Location:27 → 129
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    3. NM_140350.5 → NP_648607.3  WW domain binding protein 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648607.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU19
      Conserved Domains (1) summary
      cd13214
      Location:27 → 129
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    4. NM_001274857.2 → NP_001261786.1  WW domain binding protein 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFH0
      Conserved Domains (1) summary
      cd13214
      Location:27 → 129
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    5. NM_001274856.2 → NP_001261785.1  WW domain binding protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF27
      Conserved Domains (2) summary
      cd13214
      Location:27 → 129
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cl23807
      Location:98 → 211
      WWbp; WW-domain ligand protein

    6. NM_001274858.2 → NP_001261787.1  WW domain binding protein 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261787.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAQ9
      Conserved Domains (1) summary
      cd13214
      Location:27 → 129
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F0JAQ9 F0JAQ9
    M9PF27 M9PF27
    M9PFH0 M9PFH0
    Q95SE8 Q95SE8
    Q9VU19 Q9VU19

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